Title Death receptors in cancer therapy / edited by Wafik S. El-Deiry

Published Totowa, N.J. : Humana Press, ©2005

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Description 1 online resource (xi, 374 pages) : illustrations Series Cancer drug discovery and development Cancer drug discovery and development. Contents Mammalian cell death pathways: intrinsic and extrinsic -- Resistance to apoptosis in cancer therapy -- Structures of TNF receptors and their interactions with ligands -- Death receptor signaling in embryonic ectodermal development -- Adaptor proteins in death receptor signalin -- Caspase activation by the extrinsic pathway -- Death signaling and therapeutic applications of TRAIL -- Death receptor mutations -- Regulation of death receptors -- Regulation of trail receptor expression in human melanoma -- Regulation of death receptors by synthetic retinoids -- Role of p53 in regulation of death receptors -- Proapoptotic gene silencing via methylation in human tumors -- Regulation of death receptor-induced apoptosis by NF-kB and interferon signaling pathways: implications for cancer therapy -- TRAIL in cancer therapy -- Expression and regulation of death receptors in multiple myeloma and prostate carcinoma -- Regulation of TRAIL-induced apoptosis by transcriptional factors -- Sensitizing tumor cells by targeting death receptor signaling inhibitors -- Ceramide, ceramidase, and FasL gene therapy in prostate cancer -- Gene therapy targeting receptor-mediated cell death the cancer -- Combination of chemotherapy and death ligands in cancer therapy Summary This is an in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. The topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death Bibliography Includes bibliographical references and index Notes English Print version record Subject Apoptosis. Cell receptors. Cancer -- Molecular aspects. Cellular signal transduction. Tumor necrosis factor -- Receptors. Neoplasms -- immunology Neoplasms -- therapy Cell Death -- immunology Genetic Therapy -- methods Receptors, Tumor Necrosis Factor Apoptosis Receptors, Cell Surface Signal Transduction SCIENCE -- Life Sciences -- Anatomy & Physiology. Cell receptors. Cancer -- Molecular aspects. Cellular signal transduction. Neoplasms -- immunology. Neoplasms -- therapy. Cell Death -- immunology. Gene Therapy -- methods. Receptors, Tumor Necrosis Factor. Apoptosis. Tumor necrosis factor -- Receptors Apoptosis Cancer -- Molecular aspects Cell receptors Cellular signal transduction Kanker. Celdood. Genen. Signalen. Form Electronic book Author El-Deiry, Wafik S LC no. 2004006682 ISBN 9781592598519 159259851X 1588291723 9781588291721

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