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Title Critical pathways to success in CNS drug development / Neal R. Cutler [and others]
Published Chichester, UK ; Hoboken, NJ : Wiley-Blackwell, 2010
Online access available from:
Wiley Online Books    View Resource Record  


Description 1 online resource (viii, 263 pages) : illustrations
Contents The impending crisis in CNS drug development -- Animal models and procedures for CNS disorders -- Pre-clinical antecedents to early human clinical trials -- Biomarkers and surrogate markers in drug development -- Neuroimaging and cognitive assessments in early drug development -- Bridging and CSF studies -- A case study from pre-clinical to early clinical trials
Summary Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials. The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Neuropsychopharmacology.
Drug development.
Critical path analysis.
Central nervous system -- Effect of drugs on -- Research -- Methodology
Central Nervous System Agents -- pharmacology
Clinical Trials as Topic -- methods
Drug Evaluation -- methods
Drug Evaluation, Preclinical -- methods
MEDICAL -- Pain Medicine.
MEDICAL -- Psychiatry -- Psychopharmacology.
Critical path analysis
Drug development
Form Electronic book
Author Cutler, Neal R.
ISBN 9781444318586