Limit search to available items
Book Cover

Title Parameters for pesticide QSAR and PBPK/PD models for human risk assessment / James B. Knaak, editor, Charles Timchalk, editor, Rogelio Tornero-Velez, editor ; sponsored by the ACS Division of Agrochemicals
Published Washington, DC : American Chemical Society, ©2012


Description 1 online resource
Series ACS symposium series ; 1099
ACS symposium series ; 1099.
Contents Parameters for pesticide QSAR and PBPK/PD models to inform human risk assessments -- Chiral chemistry and toxicity assessments for pyrethroid pesticides -- Direct chiral separation of pyrethroid isomers by HPLC with chiral stationary phases -- Biotransformation and enzymes responsible for metabolism of pyrethroids in mammals -- Characterization of potential age-related differences in pyrethroid pharmacokinetics -- 15 factors of percutaneous penetration of pesticides -- Percutaneous absorption of pesticide formulations -- Human metabolic interactions of pesticides : inhibition, induction and activation -- Paraoxonase 1 (PON1) status in risk assessment for organophosphate exposure and pharmacokinetics -- Carboxylesterases : a multifunctional enzyme involved in pesticide and lipid metabolism -- Behavioral changes in adult and young rats as indications of cholinesterase inhibition -- Comparison of esterase sensitivity, metabolic efficiency, and toxicity levels of two organophosphorus insecticides, parathion and chlorpyrifos -- Regional brain dosimetry for the organophosphorus insecticide chlorpyrifos in the preweanling rat -- Pyrethroid actions on sodium channels : isoform and species specificity -- In vitro and in vivo experimental data for development and use of pharmacokinetic models for in vitro to in vivo extrapolation of pyrethroid insecticides -- In silico strategies for modeling stereoselective metabolism of pyrethroids -- Quantitative structure-activity relationships for organophosphate enzyme inhibition -- Computational approaches for developing informative prior distributions for bayesian calibration of PBPK models -- Use of cytochrome P450-specific parameters and human biomarker data to develop a human physiologically based pharmacokinetic/pharmacodynamic model for dermal chlorpyrifos exposure -- Use of in vitro data in PBPK models : an example of in vitro to in vivo extrapolation with carbaryl
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Chemical models -- Congresses
Pharmacokinetics -- Congresses
Risk assessment -- Congresses
Structure-activity relationships (Biochemistry)
Agricultural chemicals.
Mathematical models.
Risk management.
Public health.
Health services administration.
Medical care.
Risk assessment.
QSAR (Biochemistry)
Chemical models.
Structure-Activity Relationship
Models, Theoretical
Risk Management
Toxic Actions
Pharmacological Phenomena
Publication Formats
Epidemiologic Measurements
Specialty Uses of Chemicals
Chemical Actions and Uses
Biochemical Phenomena
Organization and Administration
Phenomena and Processes
Publication Characteristics
Public Health
Physiological Phenomena
Investigative Techniques
Environment and Public Health
Health Services Administration
Chemical Phenomena
Chemicals and Drugs
Statistics as Topic
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Health Care Evaluation Mechanisms
Epidemiologic Methods
Delivery of Health Care
Quality of Health Care
Health Care Quality, Access, and Evaluation
Risk Assessment
Quantitative Structure-Activity Relationship
Models, Chemical
Patient Care Management
Patient Care Management -- methods
mathematical models.
risk management.
metabolism (biological concept)
public health.
risk assessment.
MEDICAL -- Pharmacology.
Chemical models.
Risk assessment.
Genre/Form Conference papers and proceedings.
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Knaak, James B.
Timchalk, Charles.
Tornero-Velez, Rogelio.
American Chemical Society.
American Chemical Society. Division of Agrochemicals.
ISBN 9780841226463