| Description |
1 online resource (xxvii, 479 pages) |
| Series |
Topics in medicinal chemistry ; volume 38 |
|
Topics in medicinal chemistry (Springer (Firm)) ; v. 38.
|
| Contents |
Flow Chemistry in Drug Discovery: Challenges and Opportunities / Enol López and Jesús Alcázar -- Green Aspects of Flow Chemistry for Drug Discovery / Ángel Díaz-Ortiz and Antonio de la Hoz -- Photochemistry in Flow for Drug Discovery / Thomas H. Rehm -- Electrochemistry in Flow for Drug Discovery / Bethan Winterson and Thomas Wirth -- Recent Advances of Asymmetric Catalysis in Flow for Drug Discovery / Yuki Saito and Shu Kobayashi -- Multiple Organolithium Reactions for Drug Discovery Using Flash Chemistry / Yosuke Ashikari, Takashi Tamaki, Masahiro Takumi, and Aiichiro Nagaki -- Organocatalysis in Continuous Flow for Drug Discovery / Laura Amenós, Esther Alza, and Miquel A. Pericàs -- Biocatalysis in Flow for Drug Discovery / Itziar Peñafiel and Sebastian C. Cosgrove -- Improved Synthesis of Bioactive Molecules Through Flow Chemistry / Aline Aparecida Nunes de Souza, Elida Betania Ariza Paez, Francisco Fávaro de Assis, Timothy John Brocksom, and Kleber Thiago de Oliveira -- New Biomass Reagents for the Synthesis of Bioactive Compounds / Karen Fox, Rafael Luque, Luiz Antonio Soares Romeiro, and Maria Laura Bolognesi -- Flow Chemistry Supporting Access to Drugs in Developing Countries / Cloudius R. Sagandira and Paul Watts -- Drug Discovery Automation and Library Synthesis in Flow / Paul Richardson and Irini Abdiaj |
| Summary |
This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R & D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed December 28, 2021) |
| Subject |
Drug development.
|
|
Flow chemistry.
|
|
Pharmaceutical technology.
|
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Technology, Pharmaceutical
|
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Drug Discovery
|
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Chemistry -- instrumentation
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Drug development
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Flow chemistry
|
| Form |
Electronic book
|
| Author |
Alcazar, Jesus, editor
|
|
Hoz, Antonio de la, editor.
|
|
Díaz-Ortiz, Angel, editor
|
| ISBN |
9783030855925 |
|
3030855929 |
|
