Title Bioinformatics and drug discovery / edited by Richard S. Larson

Published Totowa, N.J. : Humana Press, ©2006

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Description 1 online resource (x, 444 pages) : illustrations Series Methods in molecular biology ; 316 Methods in molecular biology (Clifton, N.J.) ; v. 316 Contents New strategies in drug discovery / Eliot H. Ohlstein [and others] -- Basic microarray analysis : strategies for successful experiments / Scott A. Ness -- From microarray to biological networks : analysis of gene expression profiles / Xiwei Wu and T. Gregory Dewey -- Microarray analysis in drug discovery and clinical applications / Siqun Wang and Qiong Cheng -- Ontology-driven approaches to analyzing data in functional genomics / Francisco Azuje, Fatima Al-Shahrour, and Joaquin Dopazo -- Gene evolution and drug discovery / James O. McInerney [and others] -- Standardization of microarray and pharmacogenomics data / Cassey S. Husser [and others] -- Clinical applications of bioinformatics, genomics, and pharmacogenomics / Omer Iqbal Protein interactions probed with mass spectrometry / Suma Kaveti and John R. Engen -- Discovering new drug targeting sites on flexible multidomain protein kinases : -- Combining segmental isotopic and site-directed spin labeling for NMR detection of interfacial clefts / Thomas K. Harris -- NMR-based screening methods for drug discovery / Laurel Sillerud and Richard S. Larson -- Receptor binding sites : bioinformatic approaches / Darren R. Flower -- In silico protein design : fitting sequence onto structure / Bassil I. Dahiyat -- Chemical database preparation for compound acquisition or virtual screening / Cristian G. Bolgna, Marius M. Olah, and Tudor I. Oprea -- Bioinformatics platform development : from gene to lead compound / Alexis S. Ivanov [and others] Summary Many of the new technologies that are transforming drug discovery require a high degree of interdisciplinary expertise in physical science, life science, and computer science for bioinformatic analysis of their output. In Bioinformatics and Drug Discovery, a panel of researchers from academic and pharmaceutical laboratories describes readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Bioinformatics and Drug Discovery makes it possible to apply in the research laboratory the powerful new technologies that promise to greatly improve and speed up the discovery of new drugs Analysis geneesmiddelen drugs bioinformatics geneesmiddelenontwikkeling drug development laboratoriummethoden laboratory methods biologische technieken biological techniques moleculaire biologie molecular biology Pharmacology Bioinformatics (General) Farmacologie Bioinformatica (algemeen) Bibliography Includes bibliographical references and index Notes English Print version record Subject Drug development. Bioinformatics. High throughput screening (Drug development) Combinatorial chemistry. Computational biology. Drugs -- Design. Genetics -- Technique. Pharmacology. Biology. Pharmaceutical chemistry. Life sciences. Medical personnel. Physical sciences. Chemistry. Pharmacogenetics. Methodology. Computational Biology -- methods Pharmacogenetics -- methods Drug Design Drug Evaluation, Preclinical Genetic Techniques Microarray Analysis Pharmacology Microchip Analytical Procedures Investigative Techniques Evaluation Studies as Topic Drug Discovery Biology Genetics Chemistry Techniques, Analytical Chemistry, Pharmaceutical Biological Science Disciplines Analytical, Diagnostic and Therapeutic Techniques and Equipment Health Occupations Natural Science Disciplines Disciplines and Occupations Chemistry Computational Biology Pharmacogenetics Methods Health Personnel Health Workforce pharmacology. biology. biological sciences. physical sciences. chemistry. methodology. MEDICAL -- Drug Guides. MEDICAL -- Pharmacology. MEDICAL -- Pharmacy. MEDICAL -- Nursing -- Pharmacology. Physical sciences Pharmacology Pharmacogenetics Pharmaceutical chemistry Methodology Medical personnel Life sciences Genetics -- Technique Drugs -- Design Computational biology Chemistry Biology Bioinformatics Combinatorial chemistry Drug development High throughput screening (Drug development) Genre/Form Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Larson, Richard S ISBN 9781592599646 1592599648 1280358769 9781280358760 9786610358762 6610358761

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