Description |
1 online resource |
Contents |
Introduction to Protein Mass Spectrometry / Ismael Cotte-Rodriguez, Zhixin Miao -- Quantitative Analysis of Therapeutic and Endogenous Peptides using LC/MS/MS Methods / Erin E. Chambers -- The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery / Timothy V. Olah, Asoka Ranasinghe -- Post-Translationally Modified Proteins: Glycosylation and Disulfide Bond Formation / Anthony Tsarbopoulos, Fotini N. Bazoti -- Mass Spectrometric Characterization in Protein Therapeutics Discovery / Jingjie Mo, Adrienne A. Tymiak, Guodong Chen -- Molecular Variants Characterization in Protein Therapeutics Development / Richard Ludwig, Jacob Bongers, Li Tao -- Mass Spectrometry of Antibody-Drug Conjugates in Plasma and Tissue in Drug Development / Surinder Kaur, Keyang Xu, Ola Saad, Luna Liu -- Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization / Hui Wei, Adrienne A. Tymiak, Guodong Chen -- Fast Photochemical Oxidation of Proteins for Structural Characterization / Lisa M. Jones -- Applications of Ion Mobility Mass Spectrometry for Characterization of Protein Therapeutics / Weibin Chen, Asish Chakraborty |
Summary |
Protein therapeutics' high efficacy, safety, and ability to treat life-threatening diseases such as cancer, inflammation and genetic disorders have revolutionized modern medicine. In 2012, 200 companies competed in this $90 billion year industry. In Characterization of Protein Therapeutics using Mass Spectrometry, expert contributors from academia and industry highlight current approaches and future trends. The book discusses mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies and quantitative approaches. The book also covers various studies involving characterization of process related protein drug impurities/degradants, metabolites, PTMs and higher order structures of protein therapeutics. General practitioners in pharmaceutical research, specialists in analytical sciences, and graduate students studying mass spectrometry and pharmaceutical sciences will find this book useful because of the step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development |
Analysis |
Chemistry |
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Pharmaceutical technology |
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Mass spectrometry |
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Biotechnology |
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Biochemistry |
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Protein Science |
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Pharmaceutical Sciences/Technology |
Notes |
Includes index |
Bibliography |
Includes bibliographical references and index |
Subject |
Protein drugs.
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Pharmaceutical chemistry.
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Chemistry, Pharmaceutical
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MEDICAL -- Pharmacology.
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Chimie.
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Science des matériaux.
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Pharmaceutical chemistry
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Protein drugs
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Form |
Electronic book
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Author |
Chen, Guodong, 1966-
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ISBN |
9781441978622 |
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1441978623 |
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