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Book Cover
E-book

Title Characterization of protein therapeutics using mass spectrometry / Guodong Chen, editor
Published New York : Springer, ©2013

Copies

Description 1 online resource
Contents Introduction to Protein Mass Spectrometry / Ismael Cotte-Rodriguez, Zhixin Miao -- Quantitative Analysis of Therapeutic and Endogenous Peptides using LC/MS/MS Methods / Erin E. Chambers -- The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery / Timothy V. Olah, Asoka Ranasinghe -- Post-Translationally Modified Proteins: Glycosylation and Disulfide Bond Formation / Anthony Tsarbopoulos, Fotini N. Bazoti -- Mass Spectrometric Characterization in Protein Therapeutics Discovery / Jingjie Mo, Adrienne A. Tymiak, Guodong Chen -- Molecular Variants Characterization in Protein Therapeutics Development / Richard Ludwig, Jacob Bongers, Li Tao -- Mass Spectrometry of Antibody-Drug Conjugates in Plasma and Tissue in Drug Development / Surinder Kaur, Keyang Xu, Ola Saad, Luna Liu -- Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization / Hui Wei, Adrienne A. Tymiak, Guodong Chen -- Fast Photochemical Oxidation of Proteins for Structural Characterization / Lisa M. Jones -- Applications of Ion Mobility Mass Spectrometry for Characterization of Protein Therapeutics / Weibin Chen, Asish Chakraborty
Summary Protein therapeutics' high efficacy, safety, and ability to treat life-threatening diseases such as cancer, inflammation and genetic disorders have revolutionized modern medicine. In 2012, 200 companies competed in this $90 billion year industry. In Characterization of Protein Therapeutics using Mass Spectrometry, expert contributors from academia and industry highlight current approaches and future trends. The book discusses mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies and quantitative approaches. The book also covers various studies involving characterization of process related protein drug impurities/degradants, metabolites, PTMs and higher order structures of protein therapeutics. General practitioners in pharmaceutical research, specialists in analytical sciences, and graduate students studying mass spectrometry and pharmaceutical sciences will find this book useful because of the step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development
Analysis Chemistry
Pharmaceutical technology
Mass spectrometry
Biotechnology
Biochemistry
Protein Science
Pharmaceutical Sciences/Technology
Notes Includes index
Bibliography Includes bibliographical references and index
Subject Protein drugs.
Pharmaceutical chemistry.
Chemistry, Pharmaceutical
MEDICAL -- Pharmacology.
Chimie.
Science des matériaux.
Pharmaceutical chemistry
Protein drugs
Form Electronic book
Author Chen, Guodong, 1966-
ISBN 9781441978622
1441978623