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Book Cover
E-book
Author Bonnett, Raymond, author.

Title Chemical Aspects of Photodynamic Therapy / Raymond Bonnett
Edition First edition
Published Boca Raton, FL : CRC Press, 2014

Copies

Description 1 online resource : text file, PDF
Series Advanced chemistry texts ; vol. 1
Advanced chemistry texts ; v. 1.
Contents Cover; Half Title; Title Page; Copyright Page; Dedication; Table of Contents; Preface; Acronyms; Chapter 1: Introduction; 1.1 Definition of Area of Study; 1.2 Historical Aspects; 1.2.1 Vitamin D and Rickets; 1.2.2 Phototherapy of Psoriasis; 1.2.3 Neonatal Hyperbilirubinemia; 1.2.4 Cancer; Bibliography; Chapter 2: Physical Matters; 2.1 Light; 2.2 Light Sources; 2.2.1 Sunlight; 2.2.2 Incandescent Lamps; 2.2.3 Arc Lamps; 2.2.4 Light-emitting Diodes; 2.2.5 Lasers; 2.3 Light Absorption; 2.3.1 The Beer-Lambert Law; 2.3.2 Excitation; 2.3.2.1 Multiplicity; 2.3.2.2 Probability; 2.4 Emission
2.5 Jablonski Diagram2.6 Quantum Efficiency; 2.7 Intermolecular Electronic Excitation Transfer; 2.8 Singlet Oxygen Quantum Yields; Bibliography; Chapter 3: Singlet Oxygen; 3.1 General; 3.2 Generation of Singlet Oxygen; 3.2.1 Chemical Methods; 3.2.2 Physical Methods; 3.3 Chemical Reactions; 3.3.1 Alkenes -- the ""ene"" Reaction; 3.3.2 Electron-rich Alkenes; 3.3.3 Conjugated Dienes -- Diels-Alder Addition; 3.3.4 Miscellaneous Reactions; Bibliography; Chapter 4: Photodynamic Action; 4.1 Definition; 4.2 Discovery and Development; 4.3 Photodynamic Agents -- Structural Types
4.3.1 General Considerations4.3.2 Structural Types; 4.4 Mechanism of Photodynamic Action; 4.4.1 The Type I Mechanism -- Electron Transfer; 4.4.2 The Type II Mechanism -- Energy Transfer; 4.4.3 Distinguishing between Type I and Type II Photooxygenation Processes; 4.4.3.1 Tests for radical intermediates (Type I mechanism); 4.4.3.2 Tests for singlet oxygen (Type II mechanism); 4.4.4 The Overall Mechanistic Picture; Bibliography; Chapter 5: Some Other Examples of Photomedicine; 5.1 Introduction; 5.2 Sunscreens; 5.2.1 Sunlight and the Skin; 5.2.2 Artificial Sunscreens; 5.3 Skin Carcinogenesis
5.4 Phototherapy of Rickets (Osteomalacia)5.5 Psoriasis; 5.5.1 Photosensitisers for PUVA; 5.5.2 Mechanism; 5.6 Phototherapy of Neonatal Hyperbilirubinemia; 5.6.1 Photofragmentation; 5.6.2 Photoisomerisation / Photosolubilisation; 5.6.2.1 Photochemical configurational isomerisation (Photobilirubins I); 5.6.2.2 Photocyclisation (Photobilirubins If lumirubins); Bibliography; Chapter 6: The Chemistry of Haematoporphyrin Derivative (HpD); 6.1 Introduction; 6.2 Chemistry of HpD Stage I; 6.3 Chemistry of HpD Stage II; 6.4 Clinical Development; Bibliography
Chapter 7: Second Generation Photosensitisers7.1 First Generation Photosensitisers; 7.1.1 Advantages; 7.1.2 Disadvantages; 7.2 Design Criteria for Second Generation Photosensitisers; 7.2.1 Dark Toxicity; 7.2.2 Composition; 7.2.3 Synthesis; 7.2.4 Solution Behaviour; 7.2.4.1 Tetraphenylporphyrin sulphonic acids; 7.2.4.2 Sulphonated metallophthalocyanines; 7.2.4.3 3-(1 -Alkyloxyethyl)-3-devinylpyropheophorbide a; 7.2.4.4 Spacing o f hydrophilic substituents on the hydrophobic framework; 7.2.5 Delivery Systems; 7.2.6 Photophysical Properties; 7.2.7 Red Absorption; Bibliography
Summary "Photodynamic therapy (PDT) is a ground breaking medical technique which uses lasers to activate light-sensitive chemicals to treat cancer and other diseases without resorting to surgery. For the first time, Chemical Aspects of Photodynamic Therapy introduces in an accessible way the physics, chemistry and biology behind the technique. This highly authoritative account of the account of the rapidly developing field of PDT explores its chemical basis, while presenting information in its historical context. Haematoporphyrin derivative is considered in detail, together with the new 'second generation' photosensitisers, such as chlorins, bacteriochlorins and phthalocyanines. Photosensitisers which are currently in clinical trials are compared and reference is made to new light sources, biological and clinical findings, and prospects for future developments. This book is essential reading for new students and researchers alike studying PDT. It is recommended particularly for photochemists, as well as photobiologists and clinicians. About the authorRaymond Bonnett was born in London in 1931. After a spell in the air force, he graduated from Imperial College, going on to Cambridge to research under Alexander Todd and A.W. Johnson and then to Harvard to work with R.B. Woodward. He is now Scotia Research Professor of Chemistry at Queen Mary and Wesfield College, University of London, UK. He has been active in research on photosensitisers for 25 years and has published over 200 papers on the chemistry of porphyrins and related compounds."--Provided by publisher
Bibliography Includes bibliographical references and index
Subject Pharmaceutical chemistry.
Chemistry, Physical and theoretical.
Chemistry, Pharmaceutical
Chemistry, Physical
physical chemistry.
MEDICAL -- Pharmacology.
Chemistry, Physical and theoretical
Pharmaceutical chemistry
Form Electronic book
ISBN 9781482296952
1482296950