Title Drug stereochemistry : analytical methods and pharmacology / [edited by] Krzysztof Jozwiak, W. John Lough, Irving W. Wainer

Edition 3rd ed Published New York : Informa Healthcare, 2012

Online access available from: Taylor and Francis ebooks    View Resource Record

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Description 1 online resource (x, 322 pages) : illustrations Series Drugs and the pharmaceutical science series ; 211 Drugs and the pharmaceutical sciences ; v. 211. Contents pt. 1. Introduction -- pt. 2. The separation, preparation, and identification of stereochemically pure drugs -- pt. 3. Pharmacokinetic and pharmacodynamic differences between drug stereoisomers -- pt. 4. Perspectives on the development and use of single isomer drugs Summary "Updated to reflect modern advances in the techniques and methodology of drug stereochemistry, the Third Edition comprehensively presents all aspects of chiral drugs from scientific, academic, governmental, industrial, and clinical points of view. This stand-alone text covers the lifespan of stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. New topics in the Third Edition include: The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery; How stereochemistry impacts decisions made in the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) stages of drug discovery; A chapter on pharmacokinetics and pharmacodynamics that discusses the issues faced during the final stages of the drug development process; The impact of International Conference on Harmonisation on the use of single isomer drugs; Racemic switches; The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs; A chapter on the legal perspectives of patent issues surrounding racemic switches and the marketing of single enantiomer switches"--Provided by publisher Bibliography Includes bibliographical references and index Notes Print version record Subject Chiral drugs. Pharmaceutical chemistry. Stereochemistry. Stereoisomers. Chemistry, Pharmaceutical -- methods Molecular Conformation Stereoisomerism Chemistry, Pharmaceutical MEDICAL -- Drug Guides. MEDICAL -- Nursing -- Pharmacology. MEDICAL -- Pharmacology. MEDICAL -- Pharmacy. Chiral drugs. Pharmaceutical chemistry. Stereochemistry. Form Electronic book Author Jóźwiak, Krzysztof, 1971- Lough, W. J. (W. John) Wainer, Irving W ISBN 9781420092394 1420092391

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