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Author Green, William, 1950- author.

Title Contraceptive risk : the FDA, Depo-Provera, and the politics of experimental medicine / William Green
Published New York : New York University, [2017]


Description 1 online resource
Contents Introduction : the odyssey of Depo-Provera -- The Grady Hospital study : the corruption of contraceptive research -- The twenty-five-year FDA approval controversy : cancer and the politics of acceptable risk -- Contraceptive chaos : unapproved use and Upjohn v. MacMurdo -- Marketing approval and litigation : osteoporosis and the realities of medical risk -- Chemical castration : the John Hopkins Clinic and People v. Gauntlett -- Conclusions : contraceptive drug risk failure, human dignity, and a duty to act
Summary Depo-Provera is known as an injectable hormonal birth control method, but few are familiar with its dark and complicated history. Depo-Provera was tested on women since the mid-1960s without their informed consent until it was FDA-approved in 1992, but never FDA-approved as chemical castration for male sex offenders. Contraceptive risk is the author's landmark study of Depo-Provera. Based on a fascinating combination of archival materials and interviews, the book is framed as three interconnected stories told by Judith Weisz, who chaired the FDA's Public Board of Inquiry on Depo-Provera, a scientific court; by Anne MacMurdo who brought a products liability suit against Upjohn, the drug's manufacturer, for the deleterious side effects she suffered from the drug's use; and by Roger Gauntlett, an Upjohn heir who, when he was convicted of sexual assault, refused to take a dose of his family's own medicine as a probation condition. Together these three stories of Depo-Provera's convoluted fifty year odyssey call for a paradigm shift in pharmaceutical drug development. Contraceptive risk is a thoroughly researched and engrossing approach to the scientific, political and institutional forces involved in health law and policy, as well as the multifaceted politics of measuring risk.--description from back cover
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Contraception.
Women -- Health risk assessment
Contraceptives -- Safety measures
Contraception -- history
Medroxyprogesterone Acetate -- history
MEDICAL -- Gynecology & Obstetrics.
Women -- Health risk assessment
Form Electronic book
ISBN 9781479825929