| Description |
1 online resource (x, 366 pages) : illustrations |
| Series |
Methods in pharmacology and toxicology |
|
Methods in pharmacology and toxicology.
|
| Contents |
Introduction to cytokines as targets for immunomodulation / Theresa Whiteside -- Cytokine measurement tools for immunotoxicology / Rob J. Vandebriel -- The relevance of the T1/T2 paradigm in immunotoxicology: example of drug hypersensitivity reactions / Herve Lebrec and John Vasilakos -- Microbial exploitation and subversion of the human chemokine network / James Pease -- The use of cytokines in the identification and characterization of chemical allergens / Rebecca Dearman and Ian Kimber -- Inflammatory cytokines and lung toxicity / Debra L. Laskin [and others] -- Cytokine polymorphisms and relationship to disease / Berran Yucesoy [and others] -- Effects of drugs of abuse on cytokine responses / Stephen B. Pruett -- Preclinical approaches for safety assessment of cytokines / Peter T. Thomas and Melissa S. Beck-Westermeyer -- The flu-like syndrome and cytokines / Jacques Descotes and Thierry Vial -- Cytokine-induced vascular leak syndrome / Roxana Baluna -- Cytokines and autoimmune diseases: from the control of autoimmune diseases with anti-cytokine treatment to the induction of autoimmunity with cytokine treatment / Pierre Miossec -- Evaluation of antibodies in clinical trials of cytokines / Steven Swanson -- Cytokines and pharmacokinetic drug interactions / Kenneth Renton -- Evaluation of the immunological effects of cytokines administered to patients with cancer / Michael Robertson -- Clinical adverse effects of cytokines on the immune system / Thierry Vial and Jacques Descotes |
| Summary |
Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. The first section of the book is devoted to basic concepts of cytokine biology, especially as this relates to the practice of immunotoxicology. Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules. The second section provides a broad understanding of the range of cytokine activity in human disease, describing methods for assessing cytokine immunotoxicity. In the third and final section of the book, the increasingly important use of cytokines as therapeutics is explored in detail. This section includes examinations into the effects of cytokines on the immune system and in treating cancer. Timely and comprehensive, Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications will serve as both a primer and a starting point for a more detailed investigation of the role these fascinating biological regulators play in human health and disease |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| In |
Springer e-books |
| Subject |
Cytokines.
|
|
Immunotoxicology.
|
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Cytokines -- therapeutic use
|
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Cytokines -- immunology
|
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Cytokines
|
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MEDICAL -- Immunology.
|
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Immunotoxicology.
|
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Cytokines -- immunology.
|
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Cytokines -- Therapeutic use.
|
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Cytokines.
|
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Cytokines
|
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Immunotoxicology
|
| Genre/Form |
Laboratory manuals.
|
|
Manuels de laboratoire.
|
| Form |
Electronic book
|
| Author |
House, Robert V
|
|
Descotes, Jacques, 1925-
|
| ISBN |
9781588294678 |
|
1588294676 |
|
9781597453509 |
|
1597453501 |
|
1280971711 |
|
9781280971716 |
|
9786610971718 |
|
6610971714 |
|
