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Title DNA methylation : approaches, methods, and applications / edited by Manel Esteller
Published Boca Raton : CRC Press, ©2005


Description 1 online resource (223 pages) : illustrations
Contents Front Cover; Preface; Editor; Contributors; Table of Contents; 1. Impact of DNA Methylation on Health and Disease; 2. Uses of DNA Methylation in Cancer Diagnosis and Risk Assessment; 3. DNA Methylation in X Inactivation, Imprinting, and Associated Diseases; 4. Studying Mammalian DNA Methylation: Bisulfite Modification; 5. Bisulfite PCR-Based Techniques for the Study of DNA Methylation; 6. Microarray Analysis of DNA Methylation Targets Identified by Methyl-CpG-Binding Proteins; 7. Arbitrarily Primed-PCR and Related DNA Methylation Methodologies
8. Discovering DNA Methylation Differences with Restriction Landmark Genomic Scanning9. Quantitative Determination of 5-Methylcytosine DNA Content: HPCE and HPLC; 10. Qualitative Determination of 5-Methylcytosine and Other Components of the DNA Methylation Machinery: Immunofluorescence and Chromatin Immunoprecipitation; 11. Mouse Models for the Study of DNA Methylation; 12. DNA Demethylating Agents: Concepts; 13. DNA Demethylating Agents: Preclinical Evaluation as Anticancer Agents; 14. DNA Demethylating Agents: Clinical Uses; Index
Summary Describing the relation DNA methylation has to gene silencing in disease, this book explores its promising role in treating cancer. Written by leaders in the field, it outlines the best techniques to use when addressing questions concerning the cytosine methylation status of genomic DNA. Including concepts, experimental models, and clinical uses of demethylating agents, the book provides articles clarifying methodological details and more general review chapters that offer broad biological perspectives on DNA methylation. This is an invaluable handbook for researchers and clinicians interested
Bibliography Includes bibliographical references and index
Notes Print version record
Subject DNA -- Methylation -- Handbooks, manuals, etc
DNA Methylation
HEALTH & FITNESS -- Diseases -- Genetic.
MEDICAL -- Genetics.
DNA -- Methylation
Genre/Form Electronic books
Handbooks and manuals
Handbooks and manuals.
Guides et manuels.
Form Electronic book
Author Esteller, Manel
ISBN 020348701X