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Title DNA methyltransferases : role and function / Albert Jeltsch, Renata Z. Jurkowska, editors
Published [Cham] Switzerland : Springer, [2016]


Description 1 online resource (viii, 535 pages) : color illustrations
Series Advances in experimental medicine and biology, 2214-8019 ; volume 945
Advances in experimental medicine and biology ; v. 945. 0065-2598
Contents Mechanisms and biological roles of DNA methyltransferases and DNA methylation: from past achievements to future challenges / Renata Z. Jurkowska, Albert Jeltsch -- DNA and RNA pyrimidine nucleobase alkylation at the carbon-5 position / Yuri Motorin, Salifu Seidu-Larry, Mark Helm -- Bacterial DNA methylation and methylomes / Josep Casadesús -- Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases / Shoji Tajima, Isao Suetake, Kohei Takeshita, Atsushi Nakagawa, Hironobu Kimura -- Enzymology of mammalian DNA methyltransferases / Renata Z. Jurkowska, Albert Jeltsch -- Genetic studies on mammalian DNA methyltransferases / Jiameng Dan, Taiping Chen -- The role of DNA methylation in cancer / Ranjani Lakshminarasimhan, Gangning Liang -- Structure and mechanism of plant DNA methyltransferases / Jiamu Du -- DNA methylation and gene regulation in honeybees: from genome-wide analyses to obligatory epialleles / Laura Wedd, Ryszard Maleszka -- N6-methyladenine: a conserved and dynamic DNA mark / Zach Klapholz O'Brown, Eric Lieberman Greer -- Pathways of DNA demethylation / Wendy Dean -- Structure and function of TET enzymes / Xiaotong Yin, Yanhui Xu -- Proteins that read DNA methylation / Takashi Shimbo, Paul A. Wade -- DNA base flipping: a general mechanism for writing, reading, and erasing DNA modifications / Samuel Hong, Xiaodong Cheng -- Current and emerging technologies for the analysis of the genome-wide and locus-specific DNA methylation patterns / J̲örg Tost -- DNA methyltransferase inhibitors: development and applications / Marie Lopez, Ludovic Halby, Paola B. Arimondo -- Rewriting DNA methylation signatures at will: the curable genome within reach? / Sabine Stolzenburg, Désirée Goubert, Marianne G. Rots -- Engineering and directed evolution of DNA methyltransferases / Paola Laurino, Liat Rockah-Shmuel, Dan S. Tawfik -- DNA labeling using DNA methyltransferases / MiglėTomkuvienė, Edita Kriukienė, Saulius Klimaašuskas
Summary "DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics"--Publisher's description
Bibliography Includes bibliographical references
Notes Online resource; title from pdf title page (SpringerLink, viewed November 14, 2016)
Subject DNA.
DNA Modification Methylases
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
DNA -- metabolism
Medical genetics.
Cellular biology (cytology)
SCIENCE -- Life Sciences -- Biochemistry.
ADN -- métabolisme.
Méthylation de l'ADN.
DNA modification methylases.
ADN -- Méthylation.
Form Electronic book
Author Jeltsch, Albert, editor
Jurkowska, Renata Z., editor
ISBN 9783319436241