| Description |
1 online resource (xvii, 396 pages) : illustrations |
| Contents |
The central role of dendritic cells in immunity / Jessica Chu and Russell D. Salter -- Dendritic cells in cancer: emergence of the discipline / Michael R. Shurin and Michael T. Lotze -- Part I. Alterations of the dendritic cell system in cancer -- Tumor-infiltrating dendritic cells: the pathologist's perspective / Dmitry W. Gutkin -- Functional defects of dendritic cells in cancer / Mikhail M. Dikov and Irina S. Chekneva -- General properties of dendritic cell populations in cancer / Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, and Tyler J. Curiel -- Elimination of dendritic cells in cancer? Viktor Umansky and Dirk Schadendorf -- Part II. Mechanisms of dendritic cell dysfunction in cancer -- Tumor-derived factors responsible for dendritic cell dysfunction / Alberto Pinzon-Charry and J. Alejandro López -- Tumor-derived exosomes as dendritic cell modulators / Roberta Valenti [and others] -- Signaling pathways mediating dendritic cell dysfunction in cancer / Jing Yang and Qing Yi -- A role for STAT3 in dendritic cell regulation by tumor-derived factors / Dmitry I. Gabrilovich -- Tumor-associated inflammation and impact of dendritic cell function / Zoltan Pos [and others] -- Changes in dendritic cells in cancer and aging / Annabelle Grolleau-Julius and Raymond L. Yung -- Stress, immunity and dendritic cells in cancer / Rachel Kohman and Alexander W. Kusnecov -- Cancer therapy and dendritic cell immunomodulation / Galina V. Shurin, Neil Amina, and Michael R. Shurin |
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Part III. Role of dendritic cells in tumor escape -- Role IDO in dendritic cell differentiation and function in cancer / Alexey Popov and Joachim L. Schultze -- Dendritic cells: from inducers of specific T-cell responses to promoters of angiogenesis / George Coukos and Fabian Benencia -- Protumorigenic function of dendritic cells / Anjli Kukreja -- Dendritic cell maturation versus polarization in tumor escape / Michael W. Lipscomb, Walter J. Storkus, and Amy K. Wesa -- Part IV. Dendritic cells in cancer: clinical aspects -- Trafficking of dendritic cells in the tumor environment / Zoya R. Yurkovetsky and Ghena N. Yurkovetsky -- Dendritic cells in tumor-draining lymph nodes / Alistair J. Cochran [and others] -- Dendritic cell vaccines in cancer: obstacles to overcome / Ezra D. Mirvish, Rebecca G. Pomerantz, Louis D. Falo, and Larisa J. Geskin -- How best to generate dendritic cells from patients with cancer and how best to use them for immunotherapeutic purposes / Mark M. Aloysius, Richard A. Robins, and Oleg Eremin -- Genetically modified dendritic cells in cancer immunotherapy / Brian J. Morrison [and others] -- Dendritic cell tumors / Lourdes R. Ylagan -- Future directions in dendritic cell research in cancer / Madhav V. Dhodapkar |
| Summary |
Significant features of cancer are suppression and redirection of the immune response, which allow for tumor development and growth in the previously immune competent host. Central to development of immune responses are dendritic cells, and unsurprisingly these cells are strongly impacted by tumors and factors derived from them, as well as by other conditions associated with tumor progression or cancer treatments. Further, as some of the frontline strategies for treatment of cancer involve immunotherapy with ex vivo cultured or in vivo modulated dendritic cells, it becomes imperative to understand how dendritic cells interact with and are affected by the tumor microenvironment. "Dendritic Cells in Cancer," edited by Michael R. Shurin and Russell D. Salter, presents thorough analyses of the complex biology of the tumor-dendritic cell relationship, and offers insights into how cancer treatments may benefit from furthering our understanding in this area |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| In |
Springer eBooks |
| Subject |
Dendritic cells.
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Cancer -- Immunotherapy.
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Toxicology.
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Dendritic Cells -- immunology
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Dendritic Cells -- pathology
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Dendritic Cells
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Immunotherapy -- methods
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Neoplasms -- immunology
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Neoplasms -- therapy
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Toxicology
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toxicology.
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Cancer -- Immunotherapy.
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Dendritic Cells -- immunology.
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Immunotherapy.
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Neoplasms -- immunology.
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Dendritic cells.
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Sciences de la vie.
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Biomédecine.
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Cancer -- Immunotherapy
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Dendritic cells
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| Form |
Electronic book
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| Author |
Shurin, Michael R.
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Salter, Russell David, 1958-
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| LC no. |
2008940078 |
| ISBN |
9780387886114 |
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0387886117 |
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9780387886107 |
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0387886109 |
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1282126938 |
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9781282126930 |
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9786612126932 |
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6612126930 |
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