| Description |
1 online resource (x, 384 pages, 8 unnumbered pages of plates) : illustrations (some color) |
| Series |
Target organ toxicology series ; v. 27 |
|
Target organ toxicology series ; v. 27.
|
| Contents |
Role of apoptosis in normal and abnormal development / Philip Mirkes -- Signal transduction pathways as targets for teratogens / Barbara D. Abbott -- Nutrition in developmental toxicology / Deborah K. Hansen -- Epigenetic mechanisms : role of DNA methylation, histone modifications, and imprinting / Robert G. Ellis-Hutchings and John M. Rogers -- Personalized nutrition and medicine in perinatal development / Jim Kaput, James J. Chen, and William Slikker, Jr. -- Targeted gene changes affecting developmental toxicity / Sid Hunter and Phillip Hartig -- Use of mammalian in vitro systems, including embryonic stem cells, in developmental toxicity testing / Terence R.S. Ozolinš -- Zebrafish : a nonmammalian model of developmental toxicology / Kimberly C. Brannen [and others] -- Physiologically based pharmacokinetic modeling in the risk assessment of developmental toxicants / Mathieu Valcke and Kannan Krishnan -- Integration of whole animal developmental toxicity data into risk assessment / Mark E. Hurtt and Gregg D. Cappon -- Genomic approaches in developmental toxicology / George P. Daston and Jorge M. Naciff -- Comparative bioinformatics and computational toxicology / Thomas B. Knudsen and Robert J. Kavlock -- Investigating drug effects in human pregnancy / Christina D. Chambers |
| Summary |
Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional develop |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Developmental toxicology.
|
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Fetus -- Effect of drugs on.
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Teratogenic agents.
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Risk assessment.
|
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Abnormalities, Drug-Induced
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Embryonic and Fetal Development -- drug effects
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Fetal Development -- drug effects
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Embryonic Development -- drug effects
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Risk Assessment
|
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Teratogens
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risk assessment.
|
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MEDICAL -- Perinatology & Neonatology.
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Risk assessment
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Developmental toxicology
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Fetus -- Effect of drugs on
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Teratogenic agents
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| Form |
Electronic book
|
| Author |
Hansen, Deborah Kay, 1952-
|
|
Abbott, Barbara D.
|
| ISBN |
9781420054385 |
|
1420054384 |
|
