| Description |
1 online resource (xii, 471 pages) : illustrations (some color) |
| Series |
Methods in molecular biology, 1940-6029 ; 889 |
|
Methods in molecular biology (Clifton, N.J.) ; v. 889. 1064-3745
|
| Contents |
In vivo models of developmental toxicology / Jason M. Hansen -- Caenorhabditis elegans as a model in developmental toxicology / Windy A. Boyd, Marjolein V. Smith, and Jonathan H. Freedman -- Zebrafish embryo developmental toxicology assay / Julieta M. Panzica-Kelly, Cindy X. Zhang, and Karen Augustine-Rauch -- Gene knockdown by morpholino-modified oligonucleotides in the Zebrafish (Danio rerio) model : applications for developmental toxicology / Alicia R. Timme-Laragy, Sibel I. Karchner, and Mark E. Hahn -- Amphibian model for studies of developmental reproductive toxicity / Cecilia Berg -- Avian models in teratology and developmental toxicology / Susan M. Smith, George R. Flentke, and Ana Garic -- Overview of in vitro models in developmental toxicology / Craig Harris -- Primary cell and micromass culture in assessing developmental toxicity / M. Pratten -- Embryonic stem cell test : stem cell use in predicting developmental cardiotoxicity and osteotoxicity / Beatrice Kuske, Polina Y. Pulyanina, and Nicole I. zur Nieden -- Mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay / Marianne Barrier [and others] -- Murine limb bud in culture as an in vitro teratogenicity test System / France-Helene Paradis, Chunwei Huang, and Barbara F. Hales -- Rodent whole embryo culture / Craig Harris -- Rabbit whole embryo culture / Valerie A. Marshall and Edward W. Carney -- Assessment of xenobiotic biotransformation including reactive oxygen species generation in the embryo using benzene as an example / Helen J. Renaud, Allison Rutter, and Louise M. Winn -- Methodological approaches to cytochrome P450 profiling in embryos / Jared V. Goldstone and John J. Stegeman -- Analysis of Nrf2-mediated transcriptional induction of antioxidant response in early embryos / Shao-yu Chen -- Regulation and control of AP-1 binding activity in embryotoxicity / Terence R.S. Ozolins -- Thioredoxin redox status assessment during embryonic development : the redox western / Jason M. Hansen -- Methods for the determination of plasma or tissue glutathione levels / Trent E. Tipple and Lynette K. Rogers -- Oxidative stress, thiols, and redox profiles / Craig Harris and Jason M. Hansen -- Review of toxicogenomic approaches in developmental toxicology / Joshua F. Robinson, Jeroen L.A. Pennings, and Aldert H. Piersma -- Epigenetic approaches and methods in developmental toxicology: role of HDAC inhibition in teratogenic events / Elena Menegola, Graziella Cappelletti, and Francesca Di Renzo -- DNA methylation screening and analysis / Karilyn E. Sant, Muna S. Nahar, and Dana C. Dolinoy -- Assessment of histiotrophic nutrition using fluorescent probes / Jeffrey Ambroso and Craig Harris -- Diabetic embryopathy / Ulf J. Eriksson and Parri Wentzel -- Gene expression analysis in developing embryos : in situ hybridization / Siew-Ging Gong -- Assessment of gross fetal malformations : the modernized wilson technique and skeletal staining / Robert E. Seegmiller [and others] |
| Summary |
The discipline of developmental toxicology is an integration of concepts, models, and methodologies based heavily on the superimposition of toxicology principles upon the science of developmental biology. The science of developmental toxicology also borrows from other research areas that are concerned with regulation of cell growth, migration, differentiation and cell death, as such are central to the study of stem cells, cancer, and chronic diseases. In Developmental Toxicology: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study developmental toxicology highlighting the evolution of methods from classical teratology approaches to the dynamic, state-of-the-art molecular methods, systems biology, and next generation models and procedures. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Developmental Toxicology: Methods and Protocols is a valuable resource to those planning experiments to investigate consequences of environmental, nutritional, or chemical effects caused during development |
| Analysis |
Medicine |
|
Toxicology |
|
Biomedicine |
|
Pharmacology/Toxicology |
|
toxicologie |
|
ontwikkelingsstadia |
|
developmental stages |
|
teratogenese |
|
teratogenesis |
|
Environmental Toxicology, Ecotoxicology |
|
Milieutoxicologie, ecotoxicologie |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Online resource; title from PDF title page (Springer Protocols, viewed Oct. 17, 2012) |
| Subject |
Developmental toxicology -- Laboratory manuals
|
|
Toxicology.
|
|
Toxicology
|
|
toxicology.
|
|
Toxicology
|
|
Developmental toxicology
|
| Genre/Form |
Laboratory manuals
|
|
Laboratory manuals.
|
|
Manuels de laboratoire.
|
| Form |
Electronic book
|
| Author |
Harris, Craig, Ph.D.
|
|
Hansen, Jason M., Ph.D.
|
| ISBN |
9781617798672 |
|
1617798673 |
|
