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Title Animal models in diabetes research / edited by Hans-Georg Joost, Hadi Al-Hasani, Annette Schürmann
Published New York : Humana Press : Springer, ©2012

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Description 1 online resource (xi, 325 pages) : illustrations (some color)
Series Methods in molecular biology, 1940-6029 ; 933
Methods in molecular biology (Clifton, N.J.) ; v. 933. 1064-3745
Contents Non-obese diabetic (NOD) mouse as a model of human type 1 diabetes / Kritika Kachapati, David Adams, Kyle Bednar, and William M. Ridgway -- Assessment of diabetic nephropathy in the akita mouse / Jae-Hyung Chang and Susan B. Gurley -- BB rat as a model of human type 1 diabetes / Rita Bortell and Chaoxing Yang -- Diabetes in mice with monogenic obesity : the db/db mouse and its use in the study of cardiac consequences / Darrell D. Belke and David L. Severson -- Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse : a model of the human metabolic syndrome / Reinhart Kluge, Stephan Scherneck, Annette Schürmann, and Hans-Georg Joost -- TALLYHO mouse as a model of human type 2 diabetes / Jung Han Kim and Arnold M. Saxton -- Diet-induced diabetes in the sand rat (Psammomys obesus) / Nurit Kaiser, Erol Cerasi, and Gil Leibowitz -- Diabetes in zucker diabetic fatty rat / Masakazu Shiota and Richard L. Printz -- GK rat : a prototype for the study of non-overweight type 2 diabetes / Bernard Portha, Marie-Hélène Giroix, Cecile Tourrel-Cuzin, Hervé Le-Stunff, and Jamileh Movassat -- Experimentally induced rodent models of type 2 diabetes / Md. Shahidul Islam and Rachel Dorothy Wilson -- Investigation and treatment of type 2 diabetes in nonhuman primates / Barbara C. Hansen -- Determination of beta-cell function : insulin secretion of isolated islets / Michael Willenborg, Kirstin Schumacher, and Ingo Rustenbeck -- Determination of beta-cell function : ion channel function in beta cells / Martina Dufer -- Measurement of glucose homeostasis in vivo : glucose and insulin tolerance tests / Francesco Beguinot and Cecilia Nigro -- Measurement of glucose homeostasis in vivo : combination of tracers and clamp techniques / Masakazu Shiota -- Measurement of insulin sensitivity in skeletal muscle in vitro / Henrike Sell, Jørgen Jensen, and Juergen Eckel -- Beta-cell autoimmunity / Yannick F. Fuchs, Kerstin Adler, and Ezio Bonifacio -- Positional cloning of diabetes genes / Gudrun A. Brockmann and Christina Neuschl -- Retinal digest preparation : a method to study diabetic retinopathy / Nadine Dietrich and Hans-Peter Hammes -- Lineage tracing of pancreatic stem cells and beta cell regeneration / Isabelle Houbracken, Iris Mathijs, and Luc Bouwens -- Genetic lineage tracing of beta cell neogenesis / Iris Mathijs, Isabelle Houbracken, and Luc Bouwens
Summary In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular Biology series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results. Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come
Analysis endocrinologie
endocrinology
geneeskunde
medicine
biomedische wetenschappen
biomedicine
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Diabetes -- Animal models
Diseases -- Animal models.
Laboratory animals.
Diabetes Mellitus, Experimental
Disease Models, Animal
Animals, Laboratory
Models, Animal
Laboratory animals
Diseases -- Animal models
Diabetes -- Animal models
Genre/Form Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Joost, Hans-Georg.
Al-Hasani, Hadi.
Schurmann, Annette.
ISBN 9781627030687
1627030689