| Description |
1 online resource (818 pages) |
| Contents |
880-01 Cover; Title Page; Copyright; Contents; List of Contributors; Chapter 1 Marine-derived Peptides: Development and Health Prospects; 1.1 Introduction; 1.2 Development of Marine Peptides; 1.3 Health Benefits of Marine Peptides; 1.4 Conclusion; References; Chapter 2 Bioactive Proteins and Peptides from Macroalgae, Fish, Shellfish and Marine Processing Waste; 2.1 Introduction; 2.2 Macroalgal, Fish and Shellfish Proteins: Potential Sources of Bioactive Hydrolysates and Peptides; 2.2.1 Macroalgal Proteins; 2.2.2 Fish and Shellfish Proteins |
|
880-01/(S Contents note continued: 12.3.2. Anti-Proliferative Proteins and Peptides -- 12.3.3. Anti-Hypertensive Proteins and Peptides -- 12.4. Marine-algal Proteins: Potential Sources for Future Applications -- 12.4.1. Nutraceutical Value -- 12.4.2. Pharmaceutical Value -- 12.4.3. Cosmetic Value -- 12.5. Conclusion -- References -- 13. Fish Gelatin: A Versatile Ingredient for the Food and Pharmaceutical Industries / Venkateshwarlu Gudipati -- 13.1. Introduction -- 13.2. Structural Features of Fish Gelatin -- 13.3. Improvement of Functional Properties -- 13.4. Applications in the Food Industry -- 13.4.1. Gelatin Gels -- 13.4.2. Food Emulsions -- 13.4.2.1. Oxidatively-Stable Emulsions -- 13.4.3. Nutritional Supplements -- 13.4.4. Biodegradable Edible Films for Food Packaging -- 13.4.4.1. Biocomposite and Nanocomposite Films -- 13.4.4.2. Active Films for Food Preservation -- 13.5. Applications in the Pharmaceutical Industry -- 13.5.1. Fish Gelatin-based Hard and Soft Capsules -- 13.5.2. Anti-Oxidative Fish-gelatin Hydrolysates -- 13.5.3. Collagen Peptides -- 13.5.3.1. Fish-scale Collagen Peptides -- 13.5.4. Carriers in Controlled Drug Delivery -- 13.6. Conclusion -- References -- 14. Health Effects of Anti-Oxidative and Anti-Hypertensive Peptides from Marine Resources / Rune Larsen -- 14.1. Introduction -- 14.1.1. Origin of Peptides -- 14.2. Anti-Oxidative Peptides -- 14.2.1. Anti-Oxidants and Health Effects -- 14.2.1.1. Cardiovascular Diseases -- 14.2.1.2. Diabetes Mellitus -- 14.2.1.3. Neurodegenerative Disorders -- 14.2.1.4. Cancer -- 14.2.2. Anti-Oxidant Function -- 14.2.2.1. Anti-Oxidative Effects of Proteins, Peptides and Amino Acids -- 14.2.3. Evaluation of Anti-Oxidative Capacity -- 14.2.3.1. In Vitro Chemical Studies -- 14.2.3.2. In Vitro Biological Studies -- 14.2.3.3. Animal Studies -- 14.2.3.4. Human Clinical Trials -- 14.3. Anti-Hypertensive Peptides -- 14.3.1. Anti-Hypertensive Peptides and Health -- 14.3.2. Function of ACE Inhibitors -- 14.3.3. Evaluation of ACE-inhibitory Effect -- 14.3.3.1. In Vitro Studies -- 14.3.3.2. Animal Studies -- 14.3.3.3. Human Clinical Trials -- 14.3.4. Comparison of the ACE-inhibitory Capacities of Non-Marine Peptides and Commercial Products -- 14.4. Conclusion -- References -- 15. Potential Novel Therapeutics: Some Biological Aspects of Marine-derived Bioactive Peptides / Suranga P. Kodithuwakku -- 15.1. Introduction -- 15.2. Marine-derived Proteins and Biopeptides with Anti-Hypertensive Activity -- 15.2.1. 'Katsuobushi' Peptides -- 15.2.2. Sardine Peptides -- 15.2.3. Salmon Peptides -- 15.2.4. Mackeral Peptides -- 15.2.5. Shrimp Peptides -- 15.2.6. Alaska Pollock Peptides -- 15.2.7. Yellow-Fin Sole Peptides -- 15.2.8. Oyster Peptides -- 15.2.9. Tuna Peptides -- 15.2.10. Shark Peptides -- 15.2.11. Algae Peptides -- 15.2.12. Other Marine Peptides with Potent Anti-ace Properties -- 15.3. Anti-Cancer Effects of Marine-derived Bioactive Peptides -- 15.3.1. Didemin B and Aplidine -- 15.3.2. ωμλμϟμτζλ ΚΣΖΖΑ 15.3.3. Hemiasterlin/HTI-286 -- 15.3.4. Dolastatins -- 15.3.5. Kahalalide F -- 15.3.6. Cryptophycins -- 15.3.7. Neovastat/AE-941 -- 15.3.8. Vitilevuamide -- 15.3.9. Thiocoraline -- 15.3.10. Jasplakinolide -- 15.3.11. Conclusion -- 15.4. Anti-Viral Bioactivities of Marine-derived Bioactive Peptides -- 15.4.1. Papuamides -- 15.4.2. Callipeltin A -- 15.4.3. Neamphamide A -- 15.4.4. Mirabamides -- 15.4.5. Cyanovirin-N -- 15.4.6. Microspinosamide -- 15.4.7. Griffithsin -- 15.4.8. Conclusion -- 15.5. The Future of Marine Peptides as Therapeutics -- References -- 16. Hormone-like Peptides Obtained by Marine-protein Hydrolysis and Their Bioactivities / Oscar Martinez-Alvarez -- 16.1. Introduction -- 16.2. Growth Hormone-Release Peptides -- 16.3. Opioid-Like Peptides -- 16.4. Immunomodulating Peptides -- 16.5. Glucose Uptake-Stimulating Peptides -- 16.6. Secretagogue and Calciotropic Activities -- 16.7. Limitations on the use of Hormone-like Peptides as Nutraceuticals -- 16.8. Further Development and Research Needs -- References -- 17. Anti-Microbial Activities of Marine Protein and Peptides / Shiyuan Dong -- 17.1. Introduction -- 17.2. Preparation, Purification and Characterization -- 17.2.1. Preparation and Purification -- 17.2.2. Characterization -- 17.3. In Vitro Anti-Microbial Studies -- 17.3.1. Anti-Microbial Activity -- 17.3.2. The Effects of AMPs on Bacterial Cells -- 17.4. Anti-Microbial Mechanisms -- 17.4.1. Membrane-disruptive Mechanism -- 17.4.1.1. 'Barrel-stave' Model -- 17.4.1.2. 'Micellar-aggregate' Model -- 17.4.1.3. 'Carpet' Model -- 17.4.2. Non-membrane-disruptive Mechanism -- 17.5. Applications and Prospects in Food Preservation -- 17.6. Conclusion -- References -- 18. Production and Anti-Oxidant Properties of Marine-derived Bioactive Peptides / Qiukuan Wang -- 18.1. Introduction -- 18.2. Production of Antioxidant Peptides -- 18.2.1. Microbial Fermentation -- 18.2.2. Enzymatic Hydrolysis -- 18.2.2.1. Enzymatic Hydrolysis by Commercial Enzymes -- 18.2.2.2. Enzymatic Hydrolysis by Autolysis or Self-prepared Enzymes -- 18.2.3. Purification and Identification of Anti-Oxidant Peptides -- 18.3. Anti-Oxidant Mechanism and Structure-activity Relationship -- 18.3.1. Anti-Oxidant Mechanism of Bioactive Peptides -- 18.3.2. Structure-activity Relationship of Anti-Oxidant Peptides -- 18.3.2.1. Molecular Weights of Peptides -- 18.3.2.2. Hydrophobicity -- 18.3.2.3. Amino Acid Composition and Sequence -- 18.3.2.4. Histidine-containing Peptides -- 18.3.2.5. Peptide Conformation and Amino Acid Configuration -- 18.4. Industrial Applications and Perspectives -- References -- 19. Marine Peptides and Proteins with Cytotoxic and Anti-Tumoural Properties / Fernando Albericio -- 19.1. Introduction -- 19.2. Current Pipeline of Oncological Drugs Based on Natural Products -- 19.3. Current Pipeline of Marine Peptides with Anti-Tumoural Activity -- 19.4. Major Biological Sources of Marine Cytotoxic Peptides and Proteins -- 19.5. Structural Motifs in Cytotoxic Peptides -- 19.6. Cytotoxic Acyclic Peptides -- 19.7. Cytotoxic Cyclic Peptides -- 19.8. Cytotoxic (Poly)Peptides Obtained by Enzymatic Hydrolysis of Seafood -- 19.9. Cytotoxic Polypeptides -- 19.10. Conclusion -- 19.11. Acknowledgments -- References -- 20. ACE-inhibitory Activities of Marine Proteins and Peptides / Shiyuan Dong -- 20.1. Introduction -- 20.2. Determination of ACE-inhibitory Peptide Activity -- 20.2.1. In Vitro ACE-Inhibition Assay -- 20.2.2. Anti-Hypertensive-Activity Assay In Vivo -- 20.3. ACE-inhibitory Peptides from Marine Sources -- 20.3.1. ACE-Inhibitory Peptides from Fish Sources -- 20.3.2. ACE-Inhibitory Peptides from Sea Cucumber -- 20.4. Types of ACE-Inhibitor Peptide -- 20.5. Structure-Activity Relationships of ACE-Inhibitory Peptides -- 20.6. Conclusion -- References -- 21. Isolation and Biological Activities of Peptides from Marine Microalgae by Fermentation / Se-Kwon Kim -- 21.1. Introduction -- 21.2. Utilization of Fermentation to Hydrolyze Protein -- 21.3. Microalgae As a Source of Protein -- 21.4. Metabolites of Proteolytic Hydrolysis by Fermentation -- 21.5. Hydrolyzed Microalgal Peptide Application -- 21.6. Conclusion -- References -- 22. Anti-Oxidant Activities of Marine Peptides from Fish and Shrimp / Zunying Liu -- 22.1. Introduction -- 22.2. Production, Isolation, and Purification of Anti-Oxidant Peptides -- 22.3. Methods Used to Measure Anti-Oxidant Activity -- 22.3.1. In Vitro Chemical Assays -- 22.3.2. In Vitro Biological Assays and In Vivo Assays -- 22.4. Anti-Oxidant Activity of Peptides -- 22.4.1. Anti-Oxidant Peptides from Fish Sources -- 22.4.2. Anti-Oxidant Peptide from Shrimp Sources -- 22.5. Anti-Oxidant Mechanisms of Peptides -- 22.6. Applications and Prospects -- References -- 23. Fish-elastin Hydrolysate: Development and Impact on the Skin and Blood Vessels / Kenji Sato -- 23.1. Introduction -- 23.2. Starter Materials for Fish-elastin Hydrolysate -- 23.3. Preparation of Skipjack-elastin Hydrolysate -- 23.4. Impact of Ingestion of Skipjack-elastin Hydrolysate on Skin Conditions -- 23.5. Impact of Skipjack-elastin Hydrolysate on Blood Vessels -- 23.6. Safety of Skipjack-elastin Hydrolysate -- 23.7. Identification of Food-derived Elastin Peptide in Human Blood -- 23.8. Effect of Food-derived Elastin-peptide Pro-gly on Cells -- 23.9. Conclusion -- References -- 24. Free Radical-scavenging Activity of Marine Proteins and Peptides / Dai-Nghiep Ngo -- 24.1. Introduction -- 24.2. Formation of Free Radicals and Methods of Assaying Anti-Oxidant Activity -- 24.2.1. Formation of Free Radicals -- 24.2.2. Methods of Assaying Anti-Oxidant Activity -- 24.2.2.1. Anti-Oxidant Activities Using Chemical Tests -- 24.2.2.2. Anti-Oxidant Activities Using ESR Assay -- 24.3. Free Radical-scavenging Activity of Marine Proteins and Peptides -- 24.4. Conclusion -- References -- 25. Marine-derived Bioactive Peptides: Their Cardioprotective Activities and Potential Applications / M.T. Rosna -- 25.1. Introduction -- 25.2. Cardiovascular Diseases and Nutraceuticals -- 25.3. Sources of Marine Peptides -- 25.4. Development of Marine Bioactive Peptides -- 25.5. Oxidative Stress -- 25.6. Anti-Hypertensive Activity -- 25.7. Anti-Coagulant Activity -- 25.8. Conclusion -- References -- 26. Biological Activities of Marine Bioactive Peptides / Se-Kwon Kim -- 26.1. Introduction |
|
2.3 Enzymatic Hydrolysis of Macroalgal, Fish and Shellfish Processing Waste Proteins: Bioactive Protein Hydrolysates and Peptides2.3.1 In Vitro and In Vivo Cardioprotective Activity; 2.3.2 Oxidative Stress; 2.3.3 Other Biofunctionalities; 2.4 Endogenous Bioactive Peptides from Macroalgae, Fish and Shellfish; 2.5 Bioactive Proteins from Macroalgae, Fish and Shellfish; 2.6 Commercial Products Containing Marine-Derived Bioactive Protein Hydrolysates and Peptides; 2.7 Conclusion; Acknowledgement; References; Chapter 3 Lectins with Varying Specificity and Biological Activity from Marine Bivalves |
|
3.1 Introduction3.1.1 Bivalves; 3.1.1.1 Mussels; 3.1.1.2 Oysters; 3.1.1.3 Clams; 3.1.1.4 Scallops; 3.1.1.5 Cockles; 3.1.2 Innate Immunity of Invertebrates; 3.1.3 Importance of Bivalve Mollusks; 3.2 Lectins; 3.2.1 Bivalve Lectins; 3.2.1.1 C-type Lectins; 3.2.1.2 Galectins; 3.3 Isolation, Molecular Characterization and Carbohydrate Specificity of Bivalve Lectins; 3.4 Biological Functions of Bivalve Lectins; Acknowledgements; References; Chapter 4 Digestive Enzymes from Marine Sources; 4.1 Introduction; 4.2 Biodiversity and Availability; 4.3 Marine Biocatalysts; 4.3.1 Salt and pH Tolerance |
|
4.3.2 Barophilicity4.3.3 Cold Adaptivity; 4.4 Digestive Enzymes; 4.4.1 Digestive Proteases; 4.4.1.1 Acid/Aspartyl Proteases; 4.4.1.2 Serine Proteases; 4.4.1.3 Cysteine or Thiol Proteases; 4.4.1.4 Metalloproteinases; 4.5 Lipases; 4.5.1 Phospholipases; 4.5.2 Chitinolytic Enzymes; 4.5.3 Transglutaminase; 4.6 Industrial Applications; References; Chapter 5 Kamaboko Proteins as a Potential Source of Bioactive Substances; 5.1 Introduction; 5.2 Creation of Healthier and Safer Foods; 5.3 Enzymatic Modification of Food Proteins; 5.4 Kamaboko; 5.5 Chemical Properties of Kamaboko |
|
5.6 Expression of Health the Function of Kamaboko Proteins5.7 Antioxidative Activities of Kamaboko Proteins; 5.8 Angiotensin I-Converting Enzyme-Inhibitory Activities of Kamaboko Proteins; 5.9 Conclusion; References; Chapter 6 Biological Activities of Fish-protein Hydrolysates; 6.1 Introduction; 6.2 Angiotensin I-Converting Enzyme Inhibitors; 6.3 Antioxidative Properties; 6.4 Anticancer Activity; 6.5 Antimicrobial and Antiviral Activity; 6.6 Calcium-Binding Peptides; 6.7 Appetite Suppression; 6.8 Anticoagulant Activity; 6.9 Immunostimulant Activity; 6.10 Hypocholesterolemic Activity |
| Summary |
Food proteins and bioactive peptides play a vital role in the growth and development of the body's structural integrity and regulation, as well as having a variety of other functional properties. Land animal-derived food proteins such as collagen and gelatine carry risks of contamination (such as BSE). Marine-derived proteins, which can provide equivalents to collagen and gelatin without the associated risks, are becoming more popular among consumers because of their numerous health beneficial effects. Most marine-derived bioactive peptides are currently underutilized. While fish and shellf |
| Notes |
6.11 Hormone-Regulating Properties |
|
Print version record |
| Subject |
Proteins -- Biotechnology
|
|
Marine pharmacology.
|
|
Food industry and trade.
|
|
Seafood.
|
|
Dietary Proteins -- pharmacology
|
|
Aquatic Organisms
|
|
Drug Discovery
|
|
Food Industry
|
|
Peptide Hydrolases -- pharmacology
|
|
Seafood
|
|
Seafood
|
|
Food industry and trade
|
|
Marine pharmacology
|
|
Proteins -- Biotechnology
|
| Form |
Electronic book
|
| ISBN |
9781118375105 |
|
1118375106 |
|
