Title Drug discrimination : applications to medicinal chemistry and drug studies / edited by Richard A. Glennon, Virginia Commonwealth University, Richard Young, Virginia Commonwealth University

Published Hoboken, N.J. : Wiley, ©2011

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Description 1 online resource (xx, 510 pages) : illustrations Contents Frontmatter -- Color Plates -- Part I. Part Introduction -- An Introduction to Drug Discrimination -- Methodological Considerations -- Drug Discrimination: Practical Considerations -- Role of Stereochemistry in Drug Discrimination Studies -- Drug Discrimination and In Vivo Structure₆Activity Relationships -- Drug Discrimination and Mechanisms of Drug Action -- Drug Discrimination and Development of Novel Agents and Pharmacological Tools -- Appendix -- Part II. Part Introduction -- Perceptual Drug Discriminative Aspects of the Endocannabinoid Signaling System in Animals And Man / Torbj̲rn U C J̃rbe -- Discriminative Stimulus Properties of Receptor Antagonists / Joseph H Porter -- The Discrimination of Drug Mixtures / Ian P Stolerman -- Making the Right Choice: Lessons From Drug Discrimination for Research on Drug Reinforcement And Drug Self-Administration / S Stevens Negus, Matthew L Banks -- Inhalant Drug Discrimination: Methodology, Literature Review and Future Directions / Keith L Shelton, Robert L Balster -- Drug Discrimination Studies in Rhesus Monkeys: Drug Dependence and Withdrawal / Jun-Xu Li, Lisa R Gerak, Charles P France -- Human Drug Discrimination: Methodological Considerations and Application to Elucidating the Neuropharmacology of Amphetamines / Craig R Rush, Andrea R Vansickel, William W Stoops -- Nicotine Discrimination in Humans / Kenneth A Perkins -- Drug Discrimination: A Perspective / Francis C Colpaert -- Index An introduction to drug discrimination -- Methodological considerations -- Drug discrimination : practical considerations? -- Role of stereochemistry in drug discrimination studies -- Drug discrimination and in vivo structure-activity relationships -- Drug discrimination and mechanisms of drug action -- Drug discrimination and development of novel agents and pharmacological tools -- Perceptual drug discriminative aspects of the endocannabinoid signaling system in animals and man -- Discriminative stimulus properties of receptor antagonists -- The discrimination of drug mixtures -- Making the right choice : lessons from drug discrimination for research on drug reinforcement and drug self-administration -- Inhalant drug discrimination: methodology, literature review, and future directions -- Drug discrimination studies in rhesus monkeys : drug dependence and withdrawal -- Human drug discrimination : methodological considerations and application to elucidating the neuropharmacology of amphetamines -- Nicotine discrimination in humans -- Drug discrimination : a perspective Summary Although somewhat labor intensive, Drug Discrimination (DD) is of enormous applicability to the understanding of drug action. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies covers the practical applications of drug discrimination studies for medicinal chemistry, including strengths and limitations versus other pharmacological methods for evaluating drug action. The book provides medicinal chemists with a fuller understanding of the nature and use of drug discrimination studies for evaluating the action of drugs while helping pharmacologists understand and better interact with medicinal chemists and drug designers when sharing pharmacologic data Bibliography Includes bibliographical references and index Notes English Print version record Subject Drug discrimination (Pharmacology) Pharmacological Phenomena Discrimination, Psychological -- drug effects Discrimination Learning -- drug effects Drug Discovery MEDICAL -- Drug Guides. MEDICAL -- Nursing -- Pharmacology. MEDICAL -- Pharmacology. MEDICAL -- Pharmacy. Drug discrimination (Pharmacology) Form Electronic book Author Glennon, Richard A., 1945- Young, Richard, 1952 October 24- LC no. 2010045225 ISBN 9781118023150 1118023153 9781118023136 1118023137 9786613239716 6613239712

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