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E-book

Title Mechanisms of DNA tumor virus transformation / volume editor, Leonard J. Rosenthal
Published Basel ; New York : Karger, 2001

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Description 1 online resource (viii, 163 pages) : illustrations
Series Monographs in virology, 0077-0965 ; vol. 23
Monographs in virology ; vol. 23
Contents Contents -- Foreword: Mechanism of Transformation -- JCV and BKV: Mechanisms of Viral Transformation -- The Bovine Papillomavirus Type-3 E5 Oncoprotein -- The Action of E6 and E7 of Human Papillomaviruses in Cellular Immortalization and Transformation -- HSV-2 Transformation: A Multistep Process Mediated by Distinct Mutagenic DNA Sequences and Viral Genes Includes Activation of the Ras/MEK/MAPK Mitogenic Pathway -- Transforming Genes of Human Cytomegalovirus and Human Herpesvirus 6 -- Transforming Genes of Human Herpesvirus 8 -- Transformation by the Epstein-Barr Virus
Summary Approximately 15% of human cancer incidence can be attributed to virus infection, i.e. viruses represent the second most important risk factor (after tobacco consumption) for cancer development in humans. Today, five virus types are known to be involved in causing human cancer: papillomaviruses, retroviruses, herpesviruses, hepadnaviruses, and flaviviruses. This volume of 'Monographs in Virology' provides a comprehensive review of a number of DNA tumor viruses. Leading experts in the field of tumor virology discuss up-to-date information, focusing on the transforming genes of DNA tumor viruses, the mechanisms of transformation and the in vitro methodology used for their identification and characterization. Even though DNA tumor viruses are a diverse group, in vitro studies have revealed several common mechanisms of viral transformation. The individual chapters of the book describe the latest research on the identification of viral oncogenes and their targets. From a medical point of view, understanding the molecular mechanisms of virus-induced cellular transformation is an essential step for the development of effective strategies to prevent and control their associated malignancies. Presented in a clear and concise manner, this book will be of great value to students as well as researchers in the fields of general biology, molecular biology, cell biology and microbiology
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Oncogenic viruses.
Viral cell transformation.
Viral carcinogenesis.
DNA Tumor Viruses -- physiology
Cell Transformation, Viral
Neoplasms -- etiology
Oncogenic Viruses
Oncogenic viruses
Viral carcinogenesis
Viral cell transformation
Transformation cellulaire virale.
Virus oncogène.
Tumeurs -- étiologie.
Virus oncogènes à ADN.
DNS-Tumorviren -- Maligne Transformation -- Aufsatzsammlung.
Maligne Transformation -- DNS-Tumorviren -- Aufsatzsammlung.
DNA Viruses.
Molecular Biology.
Cellular Biology.
Neoplasms.
Genetic Transformation.
Human Herpesvirus.
Papillomavirus.
Carcinogenese
DNS-Tumorviren
Maligne Transformation
Genre/Form Aufsatzsammlung.
Form Electronic book
Author Rosenthal, Leonard J
ISBN 9783318007220
3318007226