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Book Cover
Author Merchant, Kalpana, author

Title Pharmacological Regulation of Gene Expression in the CNS Towards an Understanding of Basal Ganglial Functions (1996)
Edition First edition
Published Boca Raton, FL : CRC Press, 2017


Description 1 online resource
Series CRC Press Revivals
Contents Part, I Dopamine-Mediated Gene Expression in the Neostriatum -- chapter 1 D1 and D2 Dopamine Receptor-Mediated Gene Regulation in the Striatum / Charles R. Gerfen Kristen A. Keefe Heinz Steiner -- chapter 2 Acute and Long-Term Alterations in Immediate Early Gene Expression By Antipsychotic Drugs: Downstream Genomic Targets, Behavioral Correlates, And Role of D2, D3, and D4 Receptors / Kalpana M. Merchant -- chapter 3 Dopamine Receptor Function: An Analysis Utilizing Antisense Knockout In Vivo / Bao-Cun Sun Ming Zhang Abdel-Mouttalib Ouagazzal Lynn P. Martin James M. Tepper Ian Creese -- part, II Neurotransmitter Interactions Regulating Striatal Gene Expression -- chapter 4 Glutamatergic and Cholinergic-Regulation of Immediate-Early Gene and Neuropeptide Gene Expression in the Striatum / John Q. Wang Jacqueline F. McGinty -- chapter 5 Molecular Mechanisms of Striatal Gene Regulation: A critical role for Glutamate in Dopamine-Mediated Gene Induction / Steven E. Hyman Rebecca L. Cole Michael Schwarzschild Douglas Cole Bruce Hope Christine Konradi -- part, III Persistent Alterations in Gene Expression Involved in Behavioral Adaptations -- chapter 6 Striatal Gene Expression Involved in Adaptive Responses to Levodopa in Parkinsonian Models: Relevance to Long-Term Clinical Effects of Levodopa Therapy / George S. Robertson -- chapter 7 Plasticity of GAD Gene Expression in Animal Models of Movement Disorders / Marie-Fran├žoise Chesselet Jill M. Delfs -- chapter 8 Pharmacological and Molecular Regulation of the Expression of Dopamine Receptors / Benjamin Weiss Long-Wu Zhou Genoveva Davidkova
Summary "This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines."--Provided by publisher
Subject Dopamine -- Physiological effect
Dopamine -- Receptors.
Genetic regulation.
MEDICAL -- Physiology
Neostriatum -- Physiology
Gene Expression Regulation
SCIENCE / Life Sciences / Genetics & Genomics
MEDICAL / Pharmacology
Dopamine -- Physiological effect
Dopamine -- Receptors
Genetic regulation
Form Electronic book
ISBN 9780203711149