| Description |
1 online resource (xviii, 127 pages) : illustrations |
| Series |
Advances in experimental medicine and biology ; v. 651 |
|
Advances in experimental medicine and biology ; v. 651.
|
| Contents |
Development of the dopamine systems in zebrafish / Jörn Schweitzer and Wolfgang Driever -- Dopamine systems in the forebrain / John W. Cave and Harriet Baker -- The role of Otx genes in progenitor domains of ventral midbrain / Antonio Simeone [and others] -- Terminal differentiation of mesodiencephalic dopaminergic neurons : the role of Nurr1 and Pitx3 / Marten P. Smidt and J. Peter H. Burbach -- Foxa1 and Foxa2 transcription factors regulate differentiation of midbrain dopaminergic neurons / Siew-Lan Ang -- Transcriptional regulation of their survival : the engrailed homeobox genes / Horst H. Simon and Kambiz N. Alavian -- Neurotrophic support of midbrain dopaminergic neurons / Oliver von Bohlen und Halbach and Klaus Unsicker -- TGF-[beta] in dopamine neuron development, maintenance and neuroprotection / Eleni Roussa, Oliver von Bohlen und Halbach and Kerstin Krieglstein -- Axon guidance in the dopamine system / Asheeta A. Prasad and R. Jeroen Pasterkamp -- Protocols for generating ES-cell-derived dopamine neurons / Sonja Kriks and Lorenz Studer -- Molecular and cellular determinants for generating ES-cell-derived dopamine neurons for cell therapy / Jan Pruszak and Ole Isacson |
| Summary |
Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Dopaminergic neurons.
|
|
Neurons -- physiology
|
|
Dopamine -- physiology
|
|
Neurotransmitter Agents -- physiology
|
|
MEDICAL -- Neuroscience.
|
|
PSYCHOLOGY -- Neuropsychology.
|
|
Dopamine -- physiology.
|
|
Neurotransmitter Agents -- physiology.
|
|
Dopaminergic neurons.
|
|
Neurons -- physiology.
|
|
Sciences de la vie.
|
|
Biomédecine.
|
|
Dopaminergic neurons
|
| Genre/Form |
dissertations.
|
|
Academic theses
|
|
Academic theses.
|
|
Thèses et écrits académiques.
|
| Form |
Electronic book
|
| Author |
Pasterkamp, R. Jeroen.
|
|
Smidt, Marten P.
|
|
Burbach, Johannes Peter Henri, 1954-
|
| ISBN |
9781441903211 |
|
1441903216 |
|
9781441903228 |
|
1441903224 |
|
9781282824737 |
|
1282824732 |
|
