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Title Preclinical drug development / edited by Mark C. Rogge, David R. Taft
Edition 2nd ed
Published New York, NY : Informa Healthcare, 2010


Description 1 online resource (viii, 359 pages) : illustrations (some color)
Series Drugs and the pharmaceutical sciences ; 187
Drugs and the pharmaceutical sciences ; v. 187.
Contents The scope of preclinical drug development : an introduction and framework / Mark C. Rogge -- Lead molecule selection : pharmaceutical profiling and toxicity assessments / P.L. Bullock -- Interspecies differences in physiology and pharmacology : extrapolating preclinical data to human populations / M.N. Martinez -- Pharmacokinetics/ADME of small molecules / A.D. Ajavon and David R. Taft -- Pharmacokinetics/ADME of large molecules / R. Braeckman -- Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development / P.L. Bonate and P. Vicini -- Formulation and production strategies for enhancing bioavailability of poorly absorbed drugs / A.B. Watts and R.O. Williams III -- Transporters involved in drug disposition, toxicity, and efficacy / C.Q. Xia and G.T. Miwa -- Toxicity evaluations, ICH guidelines, and current practice / J.L. Larson -- Application of pathology in safety assessment / Robert A. Ettlin and David E. Prentice -- Utilizing the preclinical database to support clinical drug development / H. Lee
Summary Discusses the broad realm of preclinical drug development
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Drug development.
Drug Evaluation, Preclinical -- methods
Drug Industry -- methods
MEDICAL -- Drug Guides.
MEDICAL -- Pharmacology.
MEDICAL -- Pharmacy.
MEDICAL -- Nursing -- Pharmacology.
Drug development
Form Electronic book
Author Rogge, Mark C.
Taft, David R.
ISBN 9781420084733