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Book Cover
Author Shorter, Edward

Title Before Prozac : the troubled history of mood disorders in psychiatry / Edward Shorter
Published Oxford ; New York : Oxford University Press, 2009


Description 1 online resource (xvi, 304 pages)
Contents Before psychopharmacology -- The first drug set -- Power play -- Killer drugs! -- Death sentences -- "The plague of affective disorders" -- Losing ground -- What now?
Summary Psychiatry today is a barren tundra, writes medical historian Edward Shorter, where drugs that don't work are used to treat diseases that don't exist. In this provocative volume, Shorter illuminates this dismal landscape, in a revealing account of why psychiatry is "losing ground" in the struggle to treat depression. Naturally, the book looks at such culprits as the pharmaceutical industry, which is not inclined to market drugs once the patent expires, leading to the endless introduction of new--but not necessarily better--drugs. But the heart of the book focuses on an unexpected villain: the FDA, the very agency charged with ensuring drug safety and effectiveness. Shorter describes how the FDA permits companies to test new products only against placebo. If you can beat sugar pills, you get your drug licensed, whether or not it is actually better than (or even as good as) current medications, thus sweeping from the shelves drugs that may be superior but have lost patent protection. The book also examines the FDA's early power struggles against the drug industry, an influence-grab that had little to do with science, and which left barbiturates, opiates, and amphetamines all underprescribed, despite the fact that under careful supervision they are better at treating depression, with fewer side effects, than the newer drugs in the Prozac family. Shorter also castigates academia, showing how two forms of depression, melancholia and nonmelancholia--"as different from each other as chalk and cheese"--Became squeezed into one dubious classification, major depression, which was essentially a political artifact born of academic infighting. An astonishing and troubling look at modern psychiatry, Losing Ground is a book that is sure to spark controversy for years to come
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Affective disorders -- Chemotherapy -- United States -- History
Psychotropic drugs -- United States -- History
Psychopharmacology -- United States -- History
Serotonin uptake inhibitors -- Therapeutic use -- History
Psychotropic drugs industry -- United States -- History
Pharmaceutical policy -- United States -- History
Depression -- history
Drug Approval -- history
Fluoxetine -- history
Mood Disorders -- drug therapy
Psychopharmacology -- history
Psychotropic Drugs -- history
Amphetamines -- history
Antidepressive Agents -- history
Barbiturates -- history
Benzodiazepines -- history
Drug Industry -- history
Government Agencies -- history
Histamine Antagonists -- history
Selective Serotonin Reuptake Inhibitors -- therapeutic use
Selective Serotonin Reuptake Inhibitors -- history
PSYCHOLOGY -- Psychopathology -- Depression.
SELF-HELP -- Mood Disorders.
SELF-HELP -- Depression.
Affective disorders -- Chemotherapy
Pharmaceutical policy
Psychotropic drugs
Psychotropic drugs industry
United States
Genre/Form History
Form Electronic book
ISBN 9780199709335