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Title Sex and gender differences in pharmacology / Vera Regitz-Zagrosek, editor
Published Berlin ; New York : Springer, ©2012


Description 1 online resource
Series Handbook of experimental pharmacology, 0171-2004 ; v. 214
Handbook of experimental pharmacology ; v. 214.
Contents pt. 1. Sex differences in mechanisms of disease. Sex and gender differences in clinical medicine / Vera Regitz-Zagrosek and Ute Seeland -- Sex differences in animal models for cardiovascular diseases and the role of estrogen / S. Mahmoodzadeh, D. Fliegner and E. Dworatzek -- Sex differences at cellular level: "Cells have a sex" / Elisabetta Straface, Lucrezia Gambardella, Marta Brandani and Walter Malorni -- What a difference an X or Y makes: sex chromosomes, gene dose, and epigenetics in sexual differentiation / Arthur P. Arnold, Xuqi Chen and Yuichiro Itoh
pt. 2. Sex differences in pharmaco-kinetics, in drug development and use. Sex differences in drug effects: interaction with sex hormones in adult life / Ilaria Spoletini, Cristiana Vitale, Walter Malorni and Giuseppe M C Rosano -- Sex and gender in adverse drug events, addiction, and placebo / Flavia Franconi, Ilaria Campesi, Stefano Occhioni, Paola Antonini and Michael F. Murphy -- Considerations of sex and gender differences in preclinical and clinical trials / Limor Raz and Virginia M. Miller -- Gender-Specific drug prescription in germany results from prescriptions analyses / Gerd Glaeske, Cornelia Gerdau-Heitmann, Friederike Höfel and Christel Schicktanz -- Gender and polypharmacotherapy in the elderly: a clinical challenge / Christina Hofer-Dückelmann -- Role of physician gender in drug therapy / I. Gouni-Berthold and H.K. Berthold
pt. 3. Sex differences in different therapeutic areas. Sex and gender differences in cardiovascular drug therapy / Ute Seeland and Vera Regitz-Zagrosek -- Sex and gender aspects in antiarrhythmic therapy / Junko Kurokawa, Masami Kodama, Tetsushi Furukawa and Colleen E. Clancy -- Sex and gender aspects in anesthetics and pain medication / Ilaria Campesi, Marco Fois and Flavia Franconi -- Psychopharmacological treatment of mood and anxiety disorders during pregnancy / Stephanie Krüger -- Obesity and diabetes / Alexandra Kautzky-Willer and Rosa Lemmens-Gruber -- Adrenal disorders / Alois Gessl, Rosa Lemmens-Gruber and Alexandra Kautzky-Willer -- Thyroid disorders / Alois Gessl, Rosa Lemmens-Gruber and Alexandra Kautzky-Willer -- Sex-specific differences in Type 2 Diabetes Mellitus and dyslipidemia therapy: PPAR agonists / Verena Benz, Ulrich Kintscher and Anna Foryst-Ludwig -- Sex differences in the drug therapy for oncologic diseases / Oliver Schmetzer and Anne Flörcken -- Sex differences in effects and use of anti-inflammatory drugs / Svitlana Demyanets and Johann Wojta -- Treatment of irritable bowel syndrome: sex and gender specific aspects / Ulrike Voß, Anne Lewerenz and Karen Nieber -- Sex differences in prophylaxis and therapeutic treatments for viral diseases / Sabra L. Klein -- Gender differences in anticoagulation and antithrombotic therapy / Ursula Rauch -- Pharmacology and clinical use of sex steroid hormone receptor modulators / A. Cleve, K.-H. Fritzemeier, B. Haendler, N. Heinrich and C. Möller, et al
Summary This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed
Analysis Medicine
Pharmaceutical technology
Molecular Medicine
Pharmaceutical Sciences/Technology
Bibliography Includes bibliographical references and index
Notes English
In Springer eBooks
Subject Drug discrimination (Pharmacology)
Pharmacology -- Sex differences
Sex factors in disease.
Pharmacological Phenomena
Drug Therapy
Sex Factors
Sex factors in disease
Drug discrimination (Pharmacology)
Form Electronic book
Author Regitz-Zagrosek, Vera.
ISBN 9783642307263