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Book Cover
Author Lien, Eric J., 1937-

Title SAR : side effects and drug design / Eric J. Lien
Published New York : Dekker, ©1987


Description 1 online resource (x, 368 pages : illustrations.)
Series Medicinal research ; v. 11
Medicinal research ; v. 11.
Contents Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Dedication Page -- About the Series -- Preface -- Contents -- 1. Theories of Drug Action -- I. Evolution of Concepts of Drug-Receptor Interaction -- II. Occupancy Theory -- III. Rate Theory -- IV. Induced-Fit Theory: Allosteric Site and Cooperative Effect -- V. Macromolecular Perturbation Theory -- VI. The Second Messenger Concept -- VII. Active-Site-Directed Irreversible Inhibitors -- VIII. Mechanism- and Pharmacophore-Based Drug Design -- References -- 2. Improvement of Therapeutic Agents by Molecular Modification
I. Modification of the Absorption of Drugs -- II. Optimization of Time Course and Distribution by Chemical Modification -- III. Modification of the Intrinsic Pharmacological Activity -- IV. Minimization of Biodegradation of Drugs -- V. Improvement of Acceptability by Chemical Modification -- References -- 3. Quantitative Structure-Activity Relationship -- I. Dose-Response Curve and Quantitative Measurement of Biological Activity -- II. Kinetics Versus Thermodynamics -- III. Structure-Acidity-Solubility Relationship
IV. Multiple Regression Analysis and Numerical Presentation of Physicochemical Parameters -- V. QSAR of Convulsants, Anticonvulsants, and Depressants -- VI. QSAR of Narcotic Analgetics -- VII. QSAR of Antihistamines and Anticholinergics -- VIII. QSAR of Stereoisomers -- References -- 4. Ribonucleotide Reductase Inhibitors as Antiviral and Anticancer Agents -- I. Ribonucleotide Reductase (Ribonucleoside Diphosphate Reductase) as a Biochemical Target -- II. Inhibitors of RR -- References -- 5. Chemical Structure and Side Effects -- I. Extrapyramidal Syndrome
II. Bone Marrow Depression and Blood Dyscrasias -- III. Hepatotoxicity -- IV. Nephrotoxicity -- V. Ototoxicity -- VI. Skin Sensitization and Drug-Induced Eosinophilia -- VII. Glaucoma and Cataracts -- VIII. Carcinogenicity of Anticancer Drugs -- References -- Appendix -- Index
Bibliography Includes bibliographical references and index
Notes Description based on print version record
Subject Drugs -- Structure-activity relationships.
Drugs -- Side effects -- Structure-activity relationships
Pharmaceutical chemistry.
Drugs -- Side effects.
Chemical models.
Structure-activity relationships (Biochemistry)
Chemistry, Pharmaceutical
Drug-Related Side Effects and Adverse Reactions
Models, Chemical
Structure-Activity Relationship
Structure-activity relationships (Biochemistry)
Pharmaceutical chemistry
Drugs -- Side effects
Chemical models
Drugs -- Structure-activity relationships
Form Electronic book
LC no. 87005065
ISBN 9781003065715 (electronic bk)
1003065716 (electronic bk)