| Description |
1 online resource (xiii, 1446 pages) : illustrations |
| Contents |
Front Cover; REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY; REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY; Copyright; Contents; List of Contributors; I -- GENERAL; 1 -- Introduction; Reference; 2 -- Reproductive Anatomy and Physiology; INTRODUCTION; IMPORTANT DEFINITIONS AND CONCEPTS; Reproduction; Hormones and Hormone Receptors; Gonadal Steroid Hormones and Their "Nuclear" Receptors; Genomic and Nongenomic Mechanisms of Action of Gonadal Steroid Hormones; REVIEW OF NORMAL HUMAN REPRODUCTION; Historical Perspectives and Complexity of Reproductive Function |
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Relevance of a Basic Understanding of Human Reproductive Anatomy and PhysiologyNeuroendocrine Control of Reproduction; Puberty and Sexual Maturity; The Onset of Puberty; The Endocrinology of Puberty; Normal Male Reproductive Anatomy and Physiology; Developmental Perspectives; Reproductive Anatomy of the Male; Testicular Structure; Excurrent Duct System; Accessory Sex Glands; External Genitalia; Spermatogenesis; Proliferation (Mitosis or Spermatocytogenesis); Meiosis; Differentiation (Spermiogenesis); The Cycle of the Seminiferous Epithelium; Male Reproductive Physiology |
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Gonadal Steroid Synthesis in the TestesEndocrine Regulation of Spermatogenesis; Positive and Negative Feedback Loops Involved in Male Reproduction; Epididymal and Accessory Sex Gland Function; Sexual Behavior, Erection, Emission, and Ejaculation; Normal Female Reproductive Anatomy and Physiology; Developmental Perspectives; Reproductive Anatomy of the Female; Female Reproductive Physiology; The Estrous Cycle; The Menstrual Cycle; Follicular Development; Ovarian Follicular Synthesis of Estrogens; The Effects of Estrogenic Feedback on the Hypothalamic-Pituitary-Gonadal Axis; Ovulation |
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Formation and Function of a Corpus LuteumSummary of the Effects of Estrogens and Progesterone During the Female Reproductive Cycle; Oocyte/Sperm Transport, Normal Capacitation of Sperm, and Fertilization; Transport of the Ovulated Oocyte; Transport and Capacitation of Spermatozoa; Transport of Spermatozoa; Capacitation of Spermatozoa; Fertilization; Important Aspects of Normal Embryonic and Fetal Development; Historical Perspective; Blastocyst Formation and Differentiation of the Germ Cell Layers; "Maternal Recognition of Pregnancy" and Implantation; Formation of the Extraembryonic Membranes |
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Concepts and DefinitionsPlacental Types; Placental Function; The "Placental Barrier"; Sex Determination and Sexual Differentiation of Reproductive Function; Genotypic Sex and Development of the Primitive Sex Cords; Gonadal Sex Determination and Phenotypic Sexual Differentiation; Development of the Male Phenotype; Development of the Female Phenotype; Sexual Differentiation of the Brain; The Endocrinology of Pregnancy; Gestational Hormones; Parturition; Physiology of Parturition; The Mammary Glands; Anatomy; Physiology of Lactation; Lactogenesis; Control of Prolactin Secretion |
| Summary |
Of the Effects of Estrogens and Progesterone During the Female Reproductive Cycle -- Oocyte/Sperm Transport, Normal Capacitation of Sperm, and Fertilization -- Transport of the Ovulated Oocyte -- Transport and Capacitation of Spermatozoa -- Transport of Spermatozoa -- Capacitation of Spermatozoa -- Fertilization -- Important Aspects of Normal Embryonic and Fetal Development -- Historical Perspective -- Blastocyst Formation and Differentiation of the Germ Cell Layers -- "Maternal Recognition of Pregnancy" and Implantation -- Formation of the Extraembryonic Membranes -- Concepts and Definitions -- Placental Types -- Placental Function -- The "Placental Barrier"--Sex Determination and Sexual Differentiation of Reproductive Function -- Genotypic Sex and Development of the Primitive Sex Cords -- Gonadal Sex Determination and Phenotypic Sexual Differentiation -- Development of the Male Phenotype -- Development of the Female Phenotype -- Sexual Differentiation of the Brain -- The Endocrinology of Pregnancy -- Gestational Hormones -- Parturition -- Physiology of Parturition -- The Mammary Glands -- Anatomy -- Physiology of Lactation -- Lactogenesis -- Control of Prolactin Secretion -- Reproductive Senescence -- CONCLUDING REMARKS AND FUTURE DIRECTIONS -- References -- 3 - Pharmacokinetics in Pregnancy -- INTRODUCTION -- FACTORS AFFECTING PHARMACOKINETICS IN PREGNANCY -- Absorption -- Distribution -- Metabolism -- Renal Excretion -- THE FETAL COMPARTMENT -- Drug Metabolism Within the Fetal Compartment -- Drug Accumulation Within the Fetal Compartment -- HIGHLIGHTING THE VALUE OF PK INFORMATION IN PREGNANCY: TOCOLYTIC THERAPY -- MATERNAL DISEASE AND OBSTETRICAL COMPLICATIONS -- ORIGINS OF THE KNOWLEDGE GAP -- CURRENT INITIATIVES AND FUTURE DIRECTIONS -- PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING -- CONCLUDING REMARKS AND FUTURE DIRECTIONS |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Reproductive Senescence |
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Print version record |
| Subject |
Reproductive toxicology.
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Teratogens -- toxicity
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Congenital Abnormalities -- embryology
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Embryonic Development -- drug effects
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Fetal Development -- drug effects
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Toxicity Tests
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MEDICAL -- Toxicology.
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SCIENCE -- Chemistry -- Toxicology.
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Reproductive toxicology
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| Genre/Form |
Electronic books
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| Form |
Electronic book
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| Author |
Gupta, Ramesh C. (Ramesh Chandra), 1949- editor.
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| ISBN |
9780128042403 |
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0128042400 |
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