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Title Endothelin in renal physiology and disease / volume editors, Matthias Barton, Donald E. Kohan
Published Basel ; New York : Karger, ©2011


Description 1 online resource (viii, 266 pages) : illustrations (some color)
Series Contributions to nephrology, 0302-5144 ; v. 172
Contributions to nephrology ; v. 172.
Contents Cover; Contents; Preface; Molecular Biology and Physiology of Endothelin in the Kidney; Pharmacology of Renal Endothelin Receptors; Abstract; Characterizing Endothelin Receptors with Selective Agonists and Antagonists; Endothelin A Receptors and Renal Vasculature Vasoconstriction; Endothelial Endothelin B Receptors and Renal Vasculature Vasodilatation; Renal Vascular Responses in Human; Renal Vascular Responses in Rat and Mouse; Renal Vasoconstriction and Second Messengers; Does the Ratio of Endothelin Receptors Change in the Vasculature with Disease?
Endothelin B-Clearing Receptors and NatriuresisConclusions and Perspectives; Acknowledgement; References; Renal Function and Blood Pressure: Molecular Insights into the Biology of Endothelin-1; Abstract; How Endothelin-1 Regulates Blood Pressure through Kidney Function; Endothelin-1 Modulates Renal Function through Its Role as a Vasoconstrictor in the Renal Vasculature; Endothelin-1/Endothelin B Axis Regulates Fluid Volume in the Tubular System: Endothelin-1 as a Antihypertensive Agent; Pathological Features of Endothelin-1 Related to the Glomerulus; Conclusion; References
Endothelin and the Renal VasculatureAbstract; Endothelin Receptor Expression in Kidney; Effects of Endothelin on Renal Hemodynamics; Effects of Endothelin on Renal Microvascular Reactivity in vitro; Endothelin in Medullary Microcirculation; Endogenous Endothelin-1 in Regulating Renal Microvascular Tone; Endothelin in Renal Autoregulation; Endothelin- Induced Intracellular Signaling in Renal Microvessels; Impact of Endothelin-1 on Endothelial Function in Hypertension; Conclusion; Acknowledgements; References; Endothelin Signaling and Actions in the Renal Mesangium; Abstract
Endothelin Signaling and Contraction of Mesangial CellsEndothelin Signaling and Synthesis of Extracellular Matrix Proteins in Mesangial Cells; Endothelin Signaling and Proliferation of Mesangial Cells; Endothelin Signaling and Apoptosis of Mesangial Cells; Conclusion; Acknowledgements; References; Regulation of Sodium Transport in the Proximal Tubule by Endothelin; Abstract; Endothelin and Its Metabolism; Endothelin Receptors; Signal Transduction of Endothelin Receptors in the Renal Proximal Tubules; Effect of Endothelin on Renal Proximal Tubule Transport
Interaction with Other G Protein-Coupled ReceptorsEndothelin and Hypertension; Conclusion; Acknowledgements; References; Role of Endothelin in Thick Ascending Limb Sodium Chloride Transport; Abstract; Role of Endothelin-1 in Thick Ascending Limb Sodium Chloride Transport; Signaling Cascades Mediating Endothelin's Effects in Thick Ascending Limbs; Endothelin Release by Thick Ascending Limbs; Endothelin Receptor Expression and Regulation; Conclusion; References; Endothelins and Kidney Acidification; Abstract; Overview of the Kidney Response to H+ Challenges
Summary Endothelin is a 21-amino acid peptide that exerts uniquely potent and long-lasting effects on the kidney, including regulation of water and electrolyte excretion, blood pressure, cell growth, inflammation and fibrosis. During the past 10 years, the field has evolved rapidly; we are now uncovering the potential importance of endothelin receptor antagonists (ERAs) in the treatment of kidney disease. This book reviews experimental concepts, preclinical studies and clinical data which form the basis of our current understanding of the association between endothelin and kidney disease. Acclaimed experts in pharmacology, molecular biology, physiology, cardiovascular medicine, and nephrology have contributed timely reviews dealing with renal pharmacology and physiology of endothelin, the role of endothelin in renal disease development and ERAs in preclinical studies, and the current state of clinical development of ERA therapy in renal medicine. The publication at hand will be a valuable reference source for nephrologists, internists and other healthcare professionals, renal physiologists and molecular biologists, post-doctoral researchers and students in the life sciences, as well as for scientists and decision makers in drug research and development
Bibliography Includes bibliographical references and index
Subject Endothelins.
Kidneys -- Diseases.
Endothelins -- physiology
Kidney Diseases
Kidney Diseases -- drug therapy
Kidney -- physiopathology
Receptor, Endothelin A -- metabolism
MEDICAL -- Physiology.
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
Kidneys -- Diseases
Form Electronic book
Author Barton, Matthias
Kohan, Donald Elliott.
S. Karger (Firm)
ISBN 9783805597951