| Description |
1 online resource (viii, 79 pages) : illustrations, digital file |
| Series |
Colloquium series on integrated systems physiology, from molecule to function to disease, 2154-5626 ; # 28 |
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Colloquium series on integrated systems physiology, from molecule to function ; # 28. 2154-5626
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| Contents |
1. Discovery of endothelin |
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2. Basic biology of the endothelin system -- 2.1 Introduction to endothelin -- 2.2 General hemodynamic effects of the endothelin system -- 2.3 Broad framework of the renal endothelin system |
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3. Renal localization -- 3.1 Sites of production -- 3.2 Receptor distribution -- 3.2.1 Renal vascular distribution -- 3.2.2 Glomeruli -- 3.2.3 Tubular and collecting duct system -- 3.2.4 Renal medullary interstitial cells |
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4. Renal hemodynamics -- 4.1 Effects of exogenous endothelin -- 4.1.1 Total renal blood flow -- 4.1.2 Cortical microcirculation -- 4.1.3 Medullary blood flow -- 4.2 Influence of endogenous endothelins on renal perfusion |
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5. Renal tubular actions of endothelin -- 5.1 Proximal tubule -- 5.2 Thick ascending limb -- 5.3 Collecting duct -- 5.4 The renal medulla, interface of tubular and hemodynamic mechanisms |
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6. Endothelin in neural modulation of renal function -- 6.1 Sympathetic nervous system -- 6.1.1 Renin release -- 6.1.2 Tubular reabsorption -- 6.1.3 Renal vasoconstriction -- 6.2 Afferent sensory nerves -- 6.3 Endothelin-neural interactions in disease states |
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7. Physiological role of endothelin -- 7.1 Lessons from genetic models -- 7.2 Pharmacological results |
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8. Endothelin in renal pathology -- 8.1 Hypertension -- 8.1.1 Animal studies -- 8.1.2 Human studies -- 8.2 Diabetic nephropathy -- 8.3 Acute kidney injury |
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References -- Author biographies |
| Summary |
The discovery of a potent vasoconstrictor, endothelin (ET)-1, derived from vascular endothelial cells was among a variety of key lines of investigation that helped to fuel a major explosion of studies related to endothelial cell biology. This was particularly evident within the pharmaceutical industry where receptor antagonists were quickly developed and are now on the market for treatment of pulmonary hypertension and in development for other diseases such as diabetic nephropathy and cancer. Importantly, we know that the kidney contains the highest level of ET-1 production and receptor expression in the body where it has been demonstrated to function as a pro-natriuretic autocrine and paracrine factor that is activated in conditions of high salt intake. This eBook provides a review of the various mechanisms whereby ET-1 has been shown to function within the kidney through a wide range of actions that include direct effects on tubular transport, intrarenal hemodynamics, as well as neural and endocrine functions. Much has yet to be discerned, but it is clear that the ET system is a major physiological regulator of fluid-electrolyte balance and blood pressure through these renal actions |
| Analysis |
endothelin |
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ETA receptor |
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ETB receptor |
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renal blood flow |
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sodium excretion |
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diabetes |
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hypertension |
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collecting duct |
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renal nerves |
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kidney |
| Notes |
Title from PDF title page (viewed on November 16, 2011) |
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Part of: Colloquium digital library of life sciences |
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Series from website |
| Bibliography |
Includes bibliographical references (pages 59-77) |
| Subject |
Endothelins.
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Kidneys -- Physiology
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Renal circulation.
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Endothelins
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Kidney -- physiology
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Renal Circulation
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MEDICAL -- Biochemistry.
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Endothelins
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Kidneys -- Physiology
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Renal circulation
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| Form |
Electronic book
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| Author |
Boesen, Erika I
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| ISBN |
9781615042111 |
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1615042113 |
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1615042105 |
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9781615042104 |
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