| Description |
1 online resource (xiii, 272 pages) : illustrations |
| Series |
Springer protocols |
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Neuromethods, 1940-6045 ; 40 |
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Springer protocols (Series)
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Neuromethods ; 40.
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| Contents |
The nematode, Caenorhabditis elegans, as an emerging model for investigating epilepsy / Cody J. Locke, Kim A. Caldwell, and Guy A. Caldwell -- The genetics and molecular biology of seizure susceptibility in drosophila / Juan Song and Mark A. Tanouye -- The albino Xenopus laevis tadpole as a novel model of developmental seizures / D. Sesath Hewapathirane and Kurt Haas -- Zebrafish as a simple vertebrate organism for epilepsy research / Scott C. Baraban -- Modeling tuberous sclerosis complex : brain development and hyperexcitability / Devin C. Ess -- BK potassium channel mutations affecting neuronal function and epilepsy / David Petrik, Qing H. Chen, and Robert Brenner -- Mouse models of benign familial neonatal convulsions (BFNC) : mutations in KCNQ (Kv7)genes / Nanda A. Singh [and others] -- Interneuron loss as a cause of seizures : lessons from interneuron-deficient mice / Dorothy Jones-Davis, Maria-Elisa Calcagnotto, and Joy Y. Sebe -- Imaging seizure propagation in vitro / Andrew J. Trevelyan and Rafael Yuste -- Complexity untangled : large-scale realistic computational models in epilepsy / Robert J. Morgan and Ivan Soltesz -- Organotypic hippocampal slice cultures as a model of limbic epileptogenesis / Suzanne B. Bausch -- Seizure analysis and detection in vivo / Javier Echauz, Stephen Wong, and Brian Litt -- Viral vector gene therapy for epilepsy / Stacey B. Foti, Shelley J. Russek, Amy R. Brooks-Kayal, and Thomas J. McCown -- Neural stem cells in experimental mesial temporal lobe epilepsy / Michelle M. Kron and Jack M. Parent |
| Summary |
With its complex anatomical, molecular, electrophysiological and behavioral components, epilepsy provides the neuroscientist with nearly boundless opportunities to examine basic neurobiological mechanisms. In Animal Models of Epilepsy: Methods and Innovations, prominent investigators in the field examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species such as Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). While covering some traditional models, the volume also explores the newest innovations like modeling seizure activity in silica and advanced strategies for seizure detection and gene therapy. As a volume in the successful Neuromethods series, the chapters provide clear, step-by-step protocols and thought-provoking reviews of the most recent advancements in the field. Comprehensive and cutting-edge, Animal Models of Epilepsy: Methods and Innovations is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Epilepsy -- Animal models
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Epilepsy in animals.
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Epilepsy.
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Epilepsy
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Models, Animal
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Epilepsy
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Epilepsy -- Animal models
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Epilepsy in animals
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| Genre/Form |
Laboratory manuals.
|
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Manuels de laboratoire.
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| Form |
Electronic book
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| Author |
Baraban, Scott C.
|
| ISBN |
9781603272636 |
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1603272631 |
|
