Title Extracellular matrix in development / Douglas W. DeSimone, Robert P. Mecham, editors

Published Berlin ; New York : Springer, ©2013

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Description 1 online resource Series Biology of extracellular matrix, 0887-3224 Biology of extracellular matrix (Springer (Firm)) Contents Part I. Informational Signals in Extracellular Matrix and Matrix Influences on Cell Movement in the Developing Embryo. The Glycocode: Translating Heparan Sulfate Fine Structure into Developmental Function / Adam B. Cadwallader, H. Joseph Yost -- Extracellular Matrix Dynamics in Early Development / Andras Czirok, Brenda J. Rongish, Charles D. Little -- Extracellular Matrix Functions in Amphibian Gastrulation / Bette J. Dzamba, Douglas W. DeSimone -- Part II. Extracellular Matrix-Direct Morphogenesis, Growth Factor Signaling, and Maintenance of the Stem Cell Niche. Cell-ECM Interactions and the Regulation of Epithelial Branching Morphogenesis / William P. Daley, Kenneth M. Yamada -- Interactions Between Neural Crest-Derived Cells and Extracellular Microenvironment During Cardiovascular Development / Sophie Astrof -- Engineered ECM Microenvironments and Their Regulation of Stem Cells / Yu Suk Choi, Andrew W. Holle, Adam J. Engler -- Part III. Model Organisms and the Lexicon of Developmental Signals Associated with the Extracellular Matrix. ECM in Hydra Development and Regeneration / Xiaoming Zhang, Michael P. Sarras Jr -- Extracellular Matrix Remodeling in Zebrafish Development / Nathan A. Mundell, Jason R. Jessen -- The Role of HA and Has2 in the Development and Function of the Skeleton / Peter J. Roughley, Pierre Moffatt Summary Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix - secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology Analysis Life sciences Cytokines Cytology Developmental biology Cell Biology Notes Includes index Bibliography Cludes bibliographical references Subject Extracellular matrix. Developmental biology. Extracellular Matrix Developmental Biology MEDICAL -- Anatomy. SCIENCE -- Life Sciences -- Human Anatomy & Physiology. Developmental biology Extracellular matrix Form Electronic book Author DeSimone, Douglas W Mecham, Robert P ISBN 9783642359354 3642359353

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