Intro -- Contents -- Preface -- Survival needs subsistence -- Acknowledgments -- List of Abbreviations -- Chapter 1 -- Hemoglobin: A Biochemical and Molecular Overview -- Abstract -- Introduction -- Hemoglobin Research and Era of Molecular Medicine -- A Brief History of Hemoglobin Research -- Hemoglobin Heterogeneity -- Evolutionary Relationship between the Various Hemoglobin Genes -- Hemoglobin Structure -- The Structure of Adult Hemoglobin -- Primary Structure -- Secondary Structure -- Tertiary Structure -- Quaternary Structure -- The Structure of Fetal Hemoglobin
The Structure of Embryonic Hemoglobin -- Hemoglobin Synthesis -- Hemoglobin Function -- Gaseous Transport -- Carbon Monoxide as a Ligand of Hemoglobin -- Nitric Oxide and Hemoglobin Interactions -- Allosteric Effect -- What Is Allosteric Effect? -- Ligand Binding and Altered Oxygen Affinity -- Hemoglobin Genetics -- Conclusion -- Acknowledgments -- References -- Chapter 2 -- Prenatal and Postnatal Hemoglobins: Formation and Gaseous Exchange -- Abstract -- Hemoglobin Structure: An Overview -- Types of Hemoglobin -- Genetics Behind Globin Composition of Hb -- Hemoglobin Functions
Gaseous Transport -- Transport of Oxygen -- Oxygen Dissociation Curve -- Factors Affecting Oxygen Dissociation -- Transport of Carbon Dioxide -- Non-Gaseous Transport Functions of Hb -- Metabolism of Hemoglobin -- Synthesis of Hb under Normal Conditions -- Catabolism of Hemoglobin -- Hemoglobin Synthesis in Utero -- Developmental Hematopoiesis/Site and Type of Hematopoiesis -- Genetic Controls of Hemoglobin Synthesis -- Embryonic to Fetal Hb Switch -- Fetal to Adult Hemoglobin Switch -- Unique Properties of HbF -- Diffusion of Oxygen Through the Placental Membrane -- Other Properties
Hemoglobinopathies Causing Excess Hb F Formation -- Hereditary Persistence of Fetal Hemoglobin (HPFH) -- Sickle Cell Anemia -- Beta Thalassemia -- Other Conditions Causing Elevated HbF -- References -- Chapter 3 -- An Introduction to Fetal Hemoglobin and Its Characteristics -- Abstract -- Introduction -- Fetal Hemoglobin: A Brief Look of Early Research -- Fetal Hemoglobins in Other Animals -- F-Cells -- Function of HbF -- Measurement of Fetal Hemoglobin -- Structure of Fetal Hemoglobin -- Hemoglobin Variants, HbF and Hemoglobin Barts -- HbF in Pregnancy and Development
Conditions Associated with Elevated Fetal Hemoglobin Levels -- Hemoglobin F and Hereditary Persistence of Fetal Hemoglobin (HPFH) -- Sickle Cell Anemia -- Thalassemia -- Marrow Hypoplasia -- Aplastic Anemia -- Leukemia -- Thyrotoxicosis -- Acquired Increases in HbF Levels -- Therapeutics -- References -- Chapter 4 -- Regulation of the Gamma Globin Gene: Current Concepts and Perspectives -- Abstract -- Introduction -- The Role of Molecular Factors in the Regulation of Gamma Globin -- BCL11A -- LRF/ZBTB7A/Pokemon -- GATA1 -- KLF1 -- MYB -- Cis-Acting Elements -- Epigenetic Control
