| Description |
1 online resource (378 p.) |
| Contents |
Front Cover -- FIBROBLAST GROWTH FACTOR 23 -- FIBROBLAST GROWTH FACTOR 23 -- Copyright -- Contents -- Contributors -- Introduction -- 1 -- The discovery of FGF23-a historic view: genetic disorders of hypo- and hyperphosphatemia -- Introduction -- X-linked hypophosphatemic rickets -- Autosomal Dominant Hypophosphatemic Rickets -- Iron deficiency affects FGF23 status -- Tumor-induced osteomalacia -- Back to X-linked hypophosphatemic rickets -- Autosomal Recessive Hypophosphatemic Rickets -- Hyperphosphatemic disorders -- Conclusion -- References -- 2 -- FGF23-an established master regulator of phosphate metabolism -- Introduction -- Phosphorus balance -- Gastrointestinal absorption -- Intestinal epithelial luminal membrane transport -- Transcellular movement of phosphorus -- Phosphate exit at the basolateral membrane -- Renal reabsorption and excretion -- Comparison of superficial and deep nephron transport -- Cellular mechanisms of phosphate reabsorption in the kidney -- Role of proteins that interact with the type IIa Na/Pi cotransporter protein -- Regulation of homeostasis by factors that affect the urinary excretion of phosphorus -- Alterations in dietary phosphorus intake -- Effects of PTH on phosphorus reabsorption by the kidney -- Fibroblast growth factor 23 -- Phosphate homeostasis in chronic kidney disease -- References -- 3 -- Effects of FGF23 in the distal nephron -- Introduction -- Early hypothesis of distal-to-proximal FGF23 signaling in the kidney -- Physiological actions of FGF23 in the distal nephron -- Pathophysiological role of excessive FGF23 signaling in the distal nephron -- Conclusion -- References -- 4 -- The regulation of FGF23 production in bone and outside of bone -- Introduction -- FGF23 structure and function -- Regulation of FGF23 -- Noncanonical activation of FGF23 -- Extra-skeletal expression of FGF23 |
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Renal tubular phosphate reabsorption -- Vitamin D metabolism -- Renal fibrosis -- Parathyroid -- Cardiovascular system -- Cardiac hypertrophy in CKD and non-CKD -- Bone-skeletal mineralization and development -- References -- 8 -- FGF23 and bone disease -- Bone structure and function -- Role of different cell types in bone structure and function -- Paracrine and endocrine function of bone cells -- The interplay between osteocyte development and paracrine/endocrine function -- Human bone lesions associated with FGF23 excess: radiology, histology, and bone protein expression -- Autosomal dominant hypophosphatemic rickets -- Tumor-induced osteomalacia -- X-linked hypophosphatemic rickets -- Autosomal recessive hypophosphatemic rickets -- Generalized arterial calcinosis -- McCune-Albright syndrome (fibrous dysplasia) -- Gorham-Stout disease (nonhereditary, progressive osteolysis) -- Chronic kidney disease -- FGF23 as a biomarker versus cause of disease -- FGF23 potential cross-talk with Klotho -- Open questions in FGF23 and bone research -- Does FGF23 have any direct effects on bone? -- What is the interplay between osteocyte maturity, phosphate homeostasis, and FGF23 expression? -- Do agents that affect FGF23 expression do so through altering bone cell maturation? -- What are the long-term effects of FGF23 neutralizing antibodies on bone? -- Summary -- References -- 9 -- FGF23 and kidney disease -- Introduction -- FGF23 in health -- FGF23 in kidney disease -- Chronic kidney disease-mineral bone disorder -- Phosphorus -- Secondary hyperparathyroidism -- Vitamin D -- Parathyroid hormone -- Calcium -- FGF23 and anemia in CKD: iron and EPO homeostasis -- Inflammation and immunity -- FGF23 and clinical consequences in kidney disease -- Infection -- Kidney disease progression -- Mortality -- Cardiovascular disease -- Controversies and uncertainties |
| Notes |
Description based upon print version of record |
| Subject |
Fibroblast growth factors.
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Fibroblast Growth Factors
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Fibroblast growth factors
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| Form |
Electronic book
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| Author |
White, Kenneth
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Gutierrez, Orlando
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| ISBN |
9780128180372 |
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0128180374 |
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