Title Anticoagulants, antiplatelets, and thrombolytics / edited by Shaker A. Mousa

Published Totowa, N.J. : Humana Press, ©2004

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Description 1 online resource (x, 307 pages) : illustrations Series Methods in molecular medicine ; 93 Methods in molecular medicine ; 93. 1543-1894 Contents Highlights of latest advances in antithrombotics / S.A. Mousa -- Antiplatelet, anticoagulant, and thrombolytic drug interactions / O. Iqbal and S.A. Mousa -- Evaluation of platelet antagonists in in vitro flow models of thrombosis / O.J. McCarty [and others] -- Heparin and low molecular weight heparin in thrombosis, cancer, and inflammatory diseases / S.A. Mousa -- Are low molecular weight heparins the same? / S.A. Mousa -- Antithrombotic drugs for the treatment of heparin-induced thrombocytopenia / W.P. Jeske and J.M. Walenga -- Laboratory methods for heparin-induced thrombocytopenia / M. Prechel, W.P. Jeske and J.M. Walenga -- Factor Xa inhibitors / J.M. Walenga [and others] -- Tissue factor/VIIa in thrombosis and cancer / S.A. Mousa -- Tissue factor pathway inhibitor in thrombosis and beyond / S.A. Mousa [and others] -- Cell adhesion molecules: potential therapeutic and diagnostic implications / S.A. Mousa -- Development and applications of animal models of thrombosis / R.J. Shebuski [and others] -- A survey of venous thrombosis models / W.P. Jeske [and others] -- Arixtra (fondaparinux sodium) / S.A. Mousa -- Oral thrombin inhibitor ximelagatran / S.A. Mousa -- Pharmacogenomics and coagulation disorders / O. Iqbal -- Guidelines for diagnosis and treatment of deep venous thrombosis and pulmonary embolism / H. Abdel-Razeq [and others] Summary "During the past decade, remarkable progress has been made in the development of new drugs to treat thrombotic and cardiovascular diseases, the number one cause of mortality worldwide. In Anticoagulants, Antiplatelets, and Thrombolytics, leading experts with established records of discovery and invention highlight the latest developments in antithrombotics and provide experimental methods for the discovery of new and improved anticoagulants. Among the cutting-edge developments reviewed are the novel usage of low molecular weight heparins, such antithrombin agents as hirudin, and such antiplatelet drugs as the GPIIb/IIIa inhibitors and ADP-receptor antagonists. Additional innovations discussed include aspirin and clopidogrel, the expanded use of polytherapeutic approaches, antiproteases (factors IIa, Xa, and VIIa), tissue-factor targeting, platelet-receptor targeting, and antithrombin III modulation. The authors also define the clinically relevant in vitro and in vivo models of thrombosis and hemostasis that led to these advances and that will surely aid in the discovery of the next generation of antithrombotics. Up-to-date and forward-looking, Anticoagulants, Antiplatelets, and Thrombolytics illuminates the latest developments in the field of thrombosis and provides both basic and clinical investigators a broad array of successful experimental methods for the discovery and development of novel drugs to treat thrombotic and cardiovascular diseases. Book jacket."--Jacket Bibliography Includes bibliographical references and index Notes English Print version record In Springer Protocols Subject Anticoagulants (Medicine) Blood platelets. Thrombolytic therapy. Fibrinolytic agents. Anticoagulants -- therapeutic use Thrombolytic Therapy -- methods Fibrinolytic Agents -- therapeutic use Heparin -- therapeutic use Platelet Aggregation Inhibitors -- therapeutic use Thrombocytopenia -- drug therapy Anticoagulants Blood Platelets Thrombolytic Therapy Fibrinolytic Agents MEDICAL -- Pharmacology. Anticoagulants (Medicine) Blood platelets Fibrinolytic agents Thrombolytic therapy Anticoagulantia. Antitrombotica. Bloedplaatjes. Wetenschappelijke technieken. Genre/Form Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Mousa, Shaker A. ISBN 9781592596584 1592596584 1588290832 9781588290830 1280831405 9781280831409 9786610831401 6610831408

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