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Title Endocrine FGFs and klothos / edited by Makoto Kuro-o
Published New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2012


Description 1 online resource (xix, 233 pages) : illustrations
Series Advances in experimental medicine and biology ; v. 728
Advances in experimental medicine and biology ; v. 728.
Contents The Structural Biology of the FGF19 Subfamily -- Klotho and [beta]Klotho -- FGF23 and Syndromes of Abnormal Renal Phosphate Handling -- Evidence for FGF23 Involvement in a Bone-Kidney Axis Regulating Bone Mineralization and Systemic Phosphate and Vitamin D Homeostasis -- FGF23, Klotho and Vitamin D Interactions: -- What Have We Learned from In Vivo Mouse Genetics Studies? -- FGF23 and the Parathyroid -- Regulation of Ion Channels / Secreted Klotho -- FGF23 in Chronic Kidney Disease -- Secreted Klotho and Chronic Kidney Disease -- FGF23 as a Novel Therapeutic Target -- Physiology of FGF15/19 -- FGF19 and Cancer -- Understanding the Structure-Function Relationship between FGF19 and Its Mitogenic and Metabolic Activities -- FGF21 as a Therapeutic Reagent
Summary "Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors"--Provided by publisher
Analysis celbiologie
cellular biology
kidney diseases
gene expression
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Fibroblast growth factors.
Fibroblast Growth Factors -- metabolism
Endocrine System -- metabolism
Glucuronidase -- metabolism
Receptors, Fibroblast Growth Factor
Fibroblast Growth Factors
Fibroblast growth factors
Form Electronic book
Author Kuro-o, Makoto, 1960-
ISBN 9781461408871
Other Titles Endocrine fibroblast growth factors and klothos