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Title Fibrosis in disease : an organ-based guide to disease pathophysiology and therapeutic considerations / Monte S. Willis, Cecelia C. Yates, Jonathan C. Schisler, editors
Published Cham, Switzerland : Humana Press, [2019]


Description 1 online resource (474 pages)
Series Molecular and Translational Medicine
Molecular and translational medicine.
Contents Intro; Acknowledgments; Contents; Contributors; Introduction; Fibrotic Signaling in the Skin; Fibrotic Signaling in the Lung; Fibrotic Signaling in Heart; Fibrotic Signaling in the Vasculature, Liver, Kidney, and Eye; Part I: Skin, Cell Injury, and Wound Healing; Chapter 1: The Role of Chemokines in Fibrotic Dermal Remodeling and Wound Healing; Introduction; Normal Dermal Architecture and Function; Dermal Wounds; Dermal Wound Healing Is a Complex, Multistep Process that Involves Many Cell Types and Secreted Factors; The Discovery of Chemokines as Soluble Signaling Molecules
The Chemokine Family TreeChemokine Receptors and Signaling; Chemokines in the Hemostasis and Inflammation Stages of Wound Healing; Chemokines in the Proliferative Stage of Wound Healing; Chemokines in the Remodeling Stage of Wound Healing; Chemokines in the Fibrotic Phase of Healing; Conclusion; References; Chapter 2: Fibrosis and Immune Dysregulation in Systemic Sclerosis; Introduction; Epidemiology and Clinical Background; Pathogenesis: Genetic and Environmental Factors; Animal Models; Bleomycin-Induced Skin Fibrosis Mouse Model; Tight Skin-1 Mouse Model; Tight Skin-2 Mouse Model
Interleukin-6Interleukin-4; Interleukin-13; Interleukin-17; Conclusion; References; Chapter 3: Macrophage Plasticity in Skin Fibrosis; Introduction; Mechanotransduction and Macrophage Activation in Hypertrophic Scar Formation; Macrophage Alterations in the Early and Proliferating Wound with Implications in Hypertrophic Scar Formation; Macrophage Activation During Wound Remodeling and Its Association with Hypertrophic Scar Formation; Macrophages in Scleroderma; Macrophages in the Foreign Body Response and Fibrosis
Tissue-Resident Macrophage Responses in Other Forms of Fibrosis: Lessons from the Lung and LiverLung Fibrosis; Liver Fibrosis; Conclusion; References; Part II: Lung; Chapter 4: Fibrotic Signaling in the Lung; Introduction; Idiopathic Pulmonary Fibrosis: Definition and Clinical Concepts; Lung Injury and Repair; Lessons from Therapy; Epithelial Cell Signaling in Pulmonary Fibrosis; Epithelial Cell Integrity; Epithelial-Mesenchymal Transition; Epithelial Cells as Sources of Intercellular Signals; Epithelial Cell Migration
Summary This book serves as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of fibroproliferative diseases. It provides new insight into the fundamental mechanisms of classic fibrotic pathophysiologic processes like myocardial infarction, idiopathic pulmonary fibrosis, chronic kidney disease, wound healing, and systemic sclerosis. It also highlights the many new areas of therapeutic investigation currently underway. Lastly, it touches upon newly emerging fields and investigates the role of fibrosis in macular degeneration and cancer metastasis
Notes Print version record
Subject Fibrosis.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Form Electronic book
Author Willis, Monte S., editor
Yates, Cecelia C., editor
Schisler, Jonathan C., editor
ISBN 9783319981437