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Book Cover
Author Pownall, Mary Elizabeth

Title FGF signalling in vertebrate development / Mary Elizabeth Pownall and Harry V. Isaacs
Published [San Rafael, Calif.] : Morgan & Claypool Life Sciences, ©2010


Description 1 online resource (x, 75 pages) : color illustrations
Series Developmental biology ; bk. #2
Colloquium series on developmental biology ; #2.
Contents Introduction -- FGF ligands -- FGF receptors -- Heparan Sulphate Proteoglycans -- FGF signal transduction -- Regulators -- Sulfatases and Sulfotransferases -- Sprouty -- MAPK phosphatases -- Sef -- FLRT -- Integration with other signalling pathways -- Mesoderm induction -- Neural induction -- FGF signalling and posterior neural patterning -- FGF signalling at the Isthmic Organizer -- FGF signalling at the anterior neural ridge -- Morphogenesis -- Gastrulation -- Inner ear -- Lateral line -- Pronephros -- Branching morphogenesis -- The developing heart -- Somitogenesis -- FGF and myogenesis -- Limb development -- Apical ectodermal ridge -- The ZPA requires the AER and vice versa -- FGF and left-right asymmetry -- Perspectives -- References -- About the authors
Summary The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right-left asymmetry
Analysis Fibroblast growth factor
Left-right asymmetry
Map kinase phosphatase
Signal transduction
Bibliography Includes bibliographical references (pages 55-74a)
Notes Print version record
Subject User-centered system design.
Agile software development.
Fibroblast growth factors.
Fibroblast Growth Factors
Vertebrates -- growth & development
MEDICAL -- Biochemistry.
Fibroblast growth factors
Agile software development
User-centered system design
Form Electronic book
Author Isaacs, Harry V
ISBN 9781615040643