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Book Cover
Author Faul, Christian

Title Fibroblast Growth Factor 23
Published San Diego : Elsevier, 2021


Description 1 online resource (378 p.)
Contents Front Cover -- FIBROBLAST GROWTH FACTOR 23 -- FIBROBLAST GROWTH FACTOR 23 -- Copyright -- Contents -- Contributors -- Introduction -- 1 -- The discovery of FGF23-a historic view: genetic disorders of hypo- and hyperphosphatemia -- Introduction -- X-linked hypophosphatemic rickets -- Autosomal Dominant Hypophosphatemic Rickets -- Iron deficiency affects FGF23 status -- Tumor-induced osteomalacia -- Back to X-linked hypophosphatemic rickets -- Autosomal Recessive Hypophosphatemic Rickets -- Hyperphosphatemic disorders -- Conclusion -- References -- 2 -- FGF23-an established master regulator of phosphate metabolism -- Introduction -- Phosphorus balance -- Gastrointestinal absorption -- Intestinal epithelial luminal membrane transport -- Transcellular movement of phosphorus -- Phosphate exit at the basolateral membrane -- Renal reabsorption and excretion -- Comparison of superficial and deep nephron transport -- Cellular mechanisms of phosphate reabsorption in the kidney -- Role of proteins that interact with the type IIa Na/Pi cotransporter protein -- Regulation of homeostasis by factors that affect the urinary excretion of phosphorus -- Alterations in dietary phosphorus intake -- Effects of PTH on phosphorus reabsorption by the kidney -- Fibroblast growth factor 23 -- Phosphate homeostasis in chronic kidney disease -- References -- 3 -- Effects of FGF23 in the distal nephron -- Introduction -- Early hypothesis of distal-to-proximal FGF23 signaling in the kidney -- Physiological actions of FGF23 in the distal nephron -- Pathophysiological role of excessive FGF23 signaling in the distal nephron -- Conclusion -- References -- 4 -- The regulation of FGF23 production in bone and outside of bone -- Introduction -- FGF23 structure and function -- Regulation of FGF23 -- Noncanonical activation of FGF23 -- Extra-skeletal expression of FGF23
Renal tubular phosphate reabsorption -- Vitamin D metabolism -- Renal fibrosis -- Parathyroid -- Cardiovascular system -- Cardiac hypertrophy in CKD and non-CKD -- Bone-skeletal mineralization and development -- References -- 8 -- FGF23 and bone disease -- Bone structure and function -- Role of different cell types in bone structure and function -- Paracrine and endocrine function of bone cells -- The interplay between osteocyte development and paracrine/endocrine function -- Human bone lesions associated with FGF23 excess: radiology, histology, and bone protein expression -- Autosomal dominant hypophosphatemic rickets -- Tumor-induced osteomalacia -- X-linked hypophosphatemic rickets -- Autosomal recessive hypophosphatemic rickets -- Generalized arterial calcinosis -- McCune-Albright syndrome (fibrous dysplasia) -- Gorham-Stout disease (nonhereditary, progressive osteolysis) -- Chronic kidney disease -- FGF23 as a biomarker versus cause of disease -- FGF23 potential cross-talk with Klotho -- Open questions in FGF23 and bone research -- Does FGF23 have any direct effects on bone? -- What is the interplay between osteocyte maturity, phosphate homeostasis, and FGF23 expression? -- Do agents that affect FGF23 expression do so through altering bone cell maturation? -- What are the long-term effects of FGF23 neutralizing antibodies on bone? -- Summary -- References -- 9 -- FGF23 and kidney disease -- Introduction -- FGF23 in health -- FGF23 in kidney disease -- Chronic kidney disease-mineral bone disorder -- Phosphorus -- Secondary hyperparathyroidism -- Vitamin D -- Parathyroid hormone -- Calcium -- FGF23 and anemia in CKD: iron and EPO homeostasis -- Inflammation and immunity -- FGF23 and clinical consequences in kidney disease -- Infection -- Kidney disease progression -- Mortality -- Cardiovascular disease -- Controversies and uncertainties
Notes Description based upon print version of record
Subject Fibroblast growth factors.
Fibroblast Growth Factors
Fibroblast growth factors
Form Electronic book
Author White, Kenneth
Gutierrez, Orlando
ISBN 9780128180372