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Author Li, Xiaokun, author.

Title Fibroblast growth factors / Xiaokun Li
Published London : Academic Press ; Beijing L Higher Education Press, [2018]


Description 1 online resource (xii, 571 pages)
Contents Preface / Wallace L. Mckeehan -- Preface / Moosa Mohammadi --
Chapter 1: Engineered Growth Factor: Engineered growth factors and cutaneous wound healing : success and possible questions in the past 10 years / Xiaobing Fu, Xiaokun Li, Baio Cheng, Wei Chen, Zhiyong Sheng --
Chapter 2: FGFs in Injury Repair and Regeneration: Regulation of autophagy and ubiquitinated protein accumulation by bFGF promotes functional recovery and neural protection in a rat model of spinal cord injury / Hongyu Zhang, Xiaokun Li -- The antiscar effects of bFGF on wound repair in vitro and in vivo / Hongxue Shi, Saverio Bellusci, Xiaokun Li, Jian Xiao -- Exogenous bFGF inhibits ER stress-induced apoptosis and improves recovery from spinal cord injury / Hongyu Zhang, Xiaokun Li, Jian Xiao -- Improved refractory wound healing with adminstration of aFGF in diabetic rats / Liyun Xie, Hongchang Gao, Xiaokun Li -- Acceleration of diabetic wound healing with PEGylated rhaFGF in healing-impaired streptozocin diabetic rats / Zhifeng Huang, Xiaokun Li -- Combined use of aFGF, G-CSF, and ZnSO₄ accelerates diabetic ulcer healing / Shaoqiang Lin, Xiaokun Li -- Acceleration of diabetic wound healing with chitosan-cross-linked collagen sponge containing rhaFGF in healing-impaired streptozocin diabetic rats / Wei Wang, Shaoqiang Lin, Lu Cai, Xiaokun Li -- Comparison of the therapeutic effects of rhaFGF and rhbFGF in wound healing in diabetic patients / Yi Tan, Lu Cai, Xiaokun Li --
Chapter 3: FGF Mutants: Cardiovascular protection of nonmitogenic haFGF from oxidative damage in vitro and in vivo / Xiaokun Li -- Retina protective effect of a FGF after cancelling its mitogenic activity / Hua Xu, Xiaokun Li -- High-level expression and purification of Tat-haFGF19--54 / Yadong Huang, Xiaokun Li -- Purification and modification of polythylene glycol of a new human basic fibroblast growth factor mutant-hbFGFSer25,87,92 / Xiaoping Wu, Xiaokun Li -- High-level expression and purification of a nonmitogenic form of haFGF in Escherichia coli / Xiaoping Wu, Xiaokun Li -- Protective effects of nonmitogenic haFGF on hydrogen peroxide-induced damage to cardiomyocytes in vitro / Zhuofeng Lin, Xiaokun Li, Xiaobing Fu -- Enhanced antiapoptosis and gut epitheilium protection function of aFGF after cancelling of its mitogenic activity / Xiaobing Fu, Xiaokun Li, Tong Wang, Biao Cheng, Zhiyong Sheng --
Chapter 4: Pathophysiology and Pharmacology of FGFs: Adiopnectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice / Zhuofeng Lin, Aimin Xu, Xiaokun Li -- bFGF inhibits ER stress induced by ischemic oxidative injury via activation of the P13K/Akt and ERK1/2 pathways / Zhouguang Wang, Xiaokun Li, Jian Xiao -- Cardiac protection bFGF from ischemia/reperfusion-induced injury in diabetic rats / Jian Xiao, Xiaokun Li -- Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB / Chaofeng Yang, Xiaokun Li, Wallace L. McKeehan, Yongde Luo -- Scrum levels of FGF21 are increased in cornorary heart disease patients and are independently associated with adverse lipid profile / Xhuofeng Lin, Xiaokun Li, Wenke Feng -- Circulates FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese / Zhuofeng Lin, Wenke Feng, Xiaokun Li -- Effects of bFGF on radiation-induced proliferation inhibition and apoptosis in thymocytes and splenocytes / Xiaokun Li --
Chapter 5: FGFs in Development and Reproductive Functions: Involvement of testicular growth factors in fetal leydig cell aggregation after exposure to phthalate in utero / Lin Han, Renshan Ge, Xiaokun Li -- Inhibition of LH-stimulated androgen production in rat immature leydig cells : effects of nuclear receptor steroidogenic factor 1 by FGF2 / Yechen Xiao, Xiaokun Li, Renshan Ge --
Chapter 6: Design and Discovery of FGF/FGFR Inhibitors: Anticancer molecules targeting FGFT / Guang Liang, Xiaokun Li -- P7 peptides suppress the proliferation of K562 cells induced by bFGF / Cong Wang, Xiaokun Li, Xiaoping Wu -- The FGF2-binding peptide P7 inhibits melanoma growth in vitro and in vivo / Yonglin Yu, Xiaoping Wu --
Chapter 7: Protein Structure and Modification of FGFs: A novel solid-phase site-specific PEGylation enhances the in vitro and in vivo biostability of RHKGF1 / Zhifeng Huang, Xiaokun Li -- Solid-phase N-terminus PEGylation of rhFGF2 on heparin-sepharose column / Zhifeng Huang, Xiaokun Li -- A better antidiabetic rhFGF21 modified with polythylene glycol / Zhifeng Huang, Xiaokun Li -- Cell-penetrating peptide TAT-mediated delivery of aFGF to retina and production against ischemia-reperfusion injury in rats / Yi Wang, Xiaokun Li -- Enhanced protection of modified haFGF with polyethylene glycol against ischemia/reperfusion-induced retinal damage in rats / Zhifeng Huang, Xiaokun Li -- Site-directed PEGylation of hbFGF / Xiaoping Wu, Xiaokyn Li --
Chapter 8: Bioengineering of FGFs and New Drug Developments: Improving the cardio protective effect of aFGF in ischemic myocardium with ultrasound-mediated cavitation of heparin-modified microbubbles : preliminary experiement / Yingzheng Zhao, Xiaokun Li -- Effects of KGF2 on coreneal epithelial wound healing in a rabbit model of carbon dioxide laser injury / Xiaojie Want, Xiaokun Li -- High levels of expression of FGF21 in transgenic tobacco (Nocotiana benthamiana) / Hongqi Fu, Xiaokun Li -- Isolation of a novel bFGF-binding peptide with potent antiangiogenetic activity / Xiaoping Wu, Xiaokun Li -- High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Excerichia coli / Huiyan Wang, Xiaokun Li -- SUMO fusion system facilitates soluble expression and high production of bioactive hFGF23 / Xiaoju Liu, Xiaokun Li
Summary Fibroblast Growth Factors presents research and results from the leading global research group on FGF, providing up-to-date and comprehensive coverage of the field. The book describes the history, basic research and growth engineering technology involved with FGFs, while also introducing detailed research methods. It comprises eight chapters that detail successes and problems in relation to wound healing of engineered growth factors and considers injury repair and regeneration, non-mitogenic mutants, structure modification, pathology, physiology, pharmacology, development, FGF/FGFR inhibitors, bioengineering, and new drug development. It will serve as a key reference book for researchers working on FGFs
Bibliography Includes bibliographical references and index
Notes Online resource; title from digital title page (viewed on September 04, 2018)
Subject Fibroblast growth factors.
Receptors, Fibroblast Growth Factor
Fibroblast Growth Factor 2
Fibroblast Growth Factors
SOCIAL SCIENCE -- Anthropology -- Physical.
Fibroblast growth factors
Form Electronic book
ISBN 9780128161432