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Book Cover
Author Athanasiou, K. A. (Kyriacos A.)

Title Engineering the knee meniscus / Kyriacos A. Athanasiou, Johannah Sanchez-Adams
Published Cham, Switzerland : Springer, ©2009
Online access available from:
Synthesis Digital Library    View Resource Record  


Description 1 online resource (97 pages) : illustrations
Series Synthesis lectures on tissue engineering ; #1
Synthesis lectures on tissue engineering ; 1.
Contents Structure-function relationships of the knee meniscus -- Anatomy and development -- Anatomy of the knee meniscus -- Development of the knee meniscus -- Biochemical composition, structure, and function -- Regional variation -- Biochemical content -- Biomechanical properties and evaluation techniques -- Geometrical considerations -- Normal loading conditions -- Shock absorption -- Collagen organization -- Biphasic behavior -- Biomechanical evaluation -- Tension -- Compression -- Shear -- Cell types -- Cell classification -- Diversity of meniscus cells -- Cell synthetic properties -- Regional variation in synthetic profiles -- Mechanosensitivity of meniscus cells -- Pathophysiology and the need for tissue engineering -- Pathophysiology and injury -- Meniscus pathology -- Osteoarthritis and meniscal degeneration -- Tears of the meniscus -- Epidemiology of meniscus tears -- The meniscus healing problem -- Introduction -- Healing in the meniscus -- Characteristics of repair tissue -- Tissue engineering and historical perspectives -- Definition of tissue engineering -- Historical perspectives -- Functional tissue engineering and the meniscus -- Tissue engineering of the knee meniscus -- Bioreactors -- Introduction -- Direct compression -- Hydrostatic pressure -- Shear -- Ultrasound -- Combinations -- Application to meniscus engineering -- In vitro tissue engineering -- Introduction -- Cell source -- Growth factors -- Synthetic scaffolds -- Natural scaffolds -- Scaffold-free approaches -- In vivo tissue engineering -- Introduction -- Animal models -- Fibrin -- Synthetic scaffolds -- Natural scaffolds -- Current therapies and future directions -- Products and current therapies -- Products involving biological materials -- Other current therapies -- Design standards -- Determining design standards -- Primary standards -- Secondary standards -- Assessments for tissue engineered constructs -- Need for functional assessment -- Functionality index -- Variable considerations -- Bibliography
Summary The knee meniscus was once thought to be a vestigial tissue, but is now known to be instrumental in imparting stability, shock absorption, load transmission, and stress distribution within the knee joint. Unfortunately, most damage to the meniscus cannot be effectively healed by the body. Meniscus tissue engineering offers a possible solution to this problem by striving to create replacement tissue that may be implanted into a defect site. With a strong focus on structure-function relationships, this book details the essential anatomical, biochemical, and mechanical aspects of this versatile tissue and reviews current meniscus tissue engineering strategies and repair techniques. We have written this text such that undergraduate students, graduate students, and researchers will find it useful as a first foray into tissue engineering, a cohesive study of the meniscus, or a reference for meniscus engineering specifications
Analysis Meniscus
Tissue engineering
Meniscus biomechanics
Meniscus tears
Functionality index
Meniscus cells
Meniscus vasculature
Alternate cell sources
Bibliography Includes bibliographical references (pages 63-80)
Subject Meniscus (Anatomy) -- Wounds and injuries -- Treatment
Knee -- Wounds and injuries -- Treatment
Tissue engineering.
Meniscus (Anatomy)
Cultures (Biology)
Medical laboratory technology.
Musculoskeletal system.
Menisci, Tibial
Knee Joint
Tissue Engineering
Culture Techniques
Clinical Laboratory Techniques
Musculoskeletal System
Investigative Techniques
Analytical, Diagnostic and Therapeutic Techniques and Equipment
MEDICAL -- Allied Health Services -- Medical Technology.
MEDICAL -- Biotechnology.
MEDICAL -- Family & General Practice.
MEDICAL -- Lasers in Medicine.
Musculoskeletal system
Meniscus (Anatomy)
Medical laboratory technology
Cultures (Biology)
Knee -- Wounds and injuries -- Treatment
Tissue engineering
Form Electronic book
Author Sanchez-Adams, Johannah.
ISBN 9781598298734
OTHER TI Synthesis digital library of engineering and computer science.