| Description |
1 online resource (462 pages) |
| Contents |
Cover; Half Title; Title Page; Copyright Page; Contents; Preface; Part 1: Technical Issues; 1. Pulse Sequence Considerations and Schemes; 1.1 Introduction; 1.2 General Considerations; 1.2.1 The Pulse Sequences; 1.2.2 More General Pulse Sequence Considerations; 1.3 Sensitivity of Particular Sequences in Parameter Space; 1.3.1 SNR Efficiencies and Optimum Parameters for UTE, FLASH and bSSFP; 1.3.2 SNR Efficiencies and Optimum Parameters for RARE; 1.4 The Best Pulse Sequence for [sup(19)]F MRI; 1.5 Implications for Actual 19F MRI Measurements |
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1.6 Further Methods to Increase SNR: Heteronuclear Overhauser Enhancement2. Advanced Detection Techniques and Hardware: Simultaneous [sup(19)]F/[sup(1)]H MRI; 2.1 Imaging Applications of Perfluorocarbon Nanoparticles and Introduction of Simultaneous 19F/1H MRI; 2.2 MRI Hardware and Reconstruction for Simultaneous [sup(19)]F/[sup(1)]H Imaging; 2.2.1 Scanner Hardware Design; 2.2.2 MR Reconstruction Methods; 2.3 [sup(19)]F/[sup(1)]H Dual-Frequency RF Coil Design and System Calibration for Simultaneous [sup(19)]F/[sup(1)]H Imaging; 2.3.1 [sup(19)]F/[sup(1)]H Dual-Frequency RF Coil Design |
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2.3.2 MR System and RF Coil Calibration for Simultaneous [sup(19)]F/[sup(1)]H Imaging2.4 Advanced MR Sequences for Simultaneous [sup(19)]F/[sup(1)]H Imaging; 2.4.1 Balanced Ultrashort TE Steady State-Free Precession Sequence; 2.4.2 Fluorine Ultrafast Turbo Spectroscopic Imaging Sequence; 2.4.3 Blood-Flow Enhanced Saturation Recovery Sequence; 2.5 Conclusion; 3. Hyperpolarization for Signal Enhancement in Fluorine MR Applications; 3.1 Introduction; 3.2 Hyperpolarization Techniques: History and Physical Principles; 3.2.1 Dynamic Nuclear Polarization |
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3.2.2 Chemically Induced Dynamic Nuclear Polarization3.2.3 Parahydrogen-Induced Polarization; 3.2.4 Application of HP Methods to MRI; 3.3 Hyperpolarized [sup(19)]F: Chronological Results; 3.3.1 DNP; 3.3.2 CIDNP; 3.3.3 PHIP; 3.4 Perspectives; Part 2: [sup(19)]F Imaging Agents; 4. Active Targeting of Perfluorocarbon Nanoemulsions; 4.1 A Short Introduction to Perfluorocarbons and Perfluorocarbon Nanoemulsions; 4.2 Generation of Targeted Perfluorocarbon Nanoemulsions; 4.2.1 Targeting Ligands; 4.2.1.1 Antibodies and antibody derivatives; 4.2.1.2 Peptides and other targeting ligands |
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4.2.2 Coupling of Targeting Ligands to PFC-NE4.2.2.1 Functional groups for coupling reactions; 4.2.2.2 Generation of targeted PFC-NE; 4.3 Applications Using Actively Targeted PFC-NE; 4.3.1 Inflammation; 4.3.1.1 Imaging immune cells; 4.3.1.2 Visualization of the activated endothelium; 4.3.1.3 Inflammation-associated angiogenesis; 4.3.2 Cancer; 4.3.3 Thrombosis; 4.3.4 Atherosclerotic Plaques and Restenosis; 4.3.5 Targeting of Stem Cells; 4.4 Summary and Outlook; 5. Responsive Probes for [sup(19)]F MRS/MRI; 5.1 Introduction; 5.2 Response Mechanisms; 5.3 Classes of [sup(19)]F Responsive Probes |
| Summary |
Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flgel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics |
| Notes |
5.3.1 pH-Activatable [sup(19)]F Probes |
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Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL |
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Print version record |
| Subject |
Magnetic resonance imaging.
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Fluorine.
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Magnetic Resonance Imaging
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Fluorine
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SCIENCE -- Spectroscopy & Spectrum Analysis.
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TECHNOLOGY & ENGINEERING -- Biomedical.
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Fluorine
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Magnetic resonance imaging
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| Form |
Electronic book
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| Author |
Ahrens, Eric
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| ISBN |
9789814745321 |
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9814745324 |
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9781315340937 |
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1315340933 |
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