Limit search to available items
Book Cover

Title Frontotemporal dementias : emerging milestones of the 21st century / Bernardino Ghetti, Emanuele Buratti, Bradley Boeve, Rosa Rademakers, editors
Published Cham, Switzerland : Springer, [2021]


Description 1 online resource (x, 320 pages) : illustrations
Series Advances in experimental medicine and biology, 0065-2598 ; volume 1281
Advances in experimental medicine and biology ; v. 1281. 0065-2598
Contents Behavioural Variant Frontotemporal Dementia: Recent Advances in the Diagnosis and Understanding of the Disorder / Rebekah M. Ahmed, John R. Hodges, and Olivier Piguet -- The Neuropsychiatric Features of Behavioral Variant Frontotemporal Dementia / Bradley T. Peet, Sheila Castro-Suarez, and Bruce L. Miller -- Nosology of Primary Progressive Aphasia and the Neuropathology of Language / M.-Marsel Mesulam, Christina Coventry, Eileen H. Bigio, Changiz Geula, Cynthia Thompson, Borna Bonakdarpour, Tamar Gefen, Emily J. Rogalski, and Sandra Weintraub -- Measuring Behavior and Social Cognition in FTLD / Katherine P. Rankin Clinical Update on C9orf72: Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, and Beyond / Dario Saracino and Isabelle Le Ber -- Clinical and Neuroimaging Aspects of Familial Frontotemporal Lobar Degeneration Associated with MAPT and GRN Mutations / Bradley F. Boeve and Howard Rosen -- Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility / Sheena I. Dev, Bradford C. Dickerson, and Alexandra Touroutoglou -- The Frontotemporal Dementia Prevention Initiative: Linking Together Genetic Frontotemporal Dementia Cohort Studies / Jonathan D. Rohrer and Adam L. Boxer -- Fluid Biomarkers of Frontotemporal Lobar Degeneration / Emma L. van der Ende and John C. van Swieten -- Frontotemporal Dementia: A Cross-Cultural Perspective / Chiadi U. Onyike, Shunichiro Shinagawa, and Ratnavalli Ellajosyula -- Progressive Supranuclear Palsy and Corticobasal Degeneration / David G. Coughlin, Dennis W. Dickson, Keith A. Josephs, and Irene Litvan -- Tau Protein and Frontotemporal Dementias / Michel Goedert, Maria Grazia Spillantini, Benjamin Falcon, Wenjuan Zhang, Kathy L. Newell, Masato Hasegawa, Sjors H.W. Scheres, and Bernardino Ghetti -- Frontotemporal Lobar Degeneration TDP-43- Immunoreactive Pathological Subtypes: Clinical and Mechanistic Significance / Manuela Neumann, Edward B. Lee, and Ian R. Mackenzie -- Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology / Xiaolai Zhou, Thomas Kukar, and Rosa Rademakers -- Trends in Understanding the Pathological Roles of TDP-43 and FUS Proteins / Emanuele BurattiA Multi-omics Data Resource for Frontotemporal Dementia Research / Peter Heutink, Kevin Menden, and Anupriya Dalmia -- Mendelian and Sporadic FTD: Disease Risk and Avenues from Genetics to Disease Pathways Through In Silico Modelling / Claudia Manzoni and Raffaele Ferrari -- FTLD Treatment: Current Practice and Future Possibilities / Peter A. Ljubenkov and Adam L. Boxer
Summary Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed March 8, 2021)
Subject Frontotemporal dementia.
Human genetics.
Frontotemporal dementia.
Human genetics.
Form Electronic book
Author Ghetti, Bernardino, editor
Buratti, Emanuele, editor
Boeve, Bradley F., editor.
Rademakers, Rosa, editor
ISBN 3030511405