Chapter 1 Metabolism and distribution of -hydroxybutyrate in the brain -- chapter 2 The -hydroxybutyrate receptor in the brain -- chapter 3 Part of the pharmacological actions of -hydroxybutyrate are mediated by GABA B receptors -- chapter 4 Membrane transport of -hydroxybutyrate -- chapter 5 Action of -hydroxybutyrate on neuronal excitability and underlying membrane conductances -- chapter 6 Regulation of central dopamine by -hydroxybutyrate -- chapter 8 -Hydroxybutyrate and absence seizure activity -- chapter 9 Behavioral pharmacology of -hydroxybutyrate -- chapter 10 Therapeutic uses of -hydroxybutyrate -- chapter 11 Abuse potential and toxicology of -hydroxybutyrate -- chapter 12 4-Hydroxybutyric aciduria -- chapter 13 -Hydroxybutyrate and oxidative stress -- chapter 14 The role of -hydroxybutyrate in brain function
Summary
Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened up a completely new line of research in an effort to establish a function for GHB. Gamma-Hydroxybutyrate: Pharmacological and Functional Aspects has brought together the combined expertise of many of the leading authorities on the biochemistry
Notes
Title from e-book title screen (viewed October 15, 2007)
