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Title Boron and gadolinium neutron capture therapy for cancer treatment / Narayan S. Hosmane [and others]
Published Singapore ; Hackensack, N.J. : World Scientific Pub. Co., [2012]
Online access available from:
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Description 1 online resource (xxiii, 246 pages) : illustrations (some color), color portraits
Contents Ch. 1. Introduction -- ch. 2. What is cancer? 2.1. Historical background. 2.2. Characteristics of tumors. 2.3. Origin of cancer. 2.4. Environmental agents. 2.5. Pathology. 2.6. Grading. 2.7. Staging. 2.8. Surgery. 2.9. Radiation therapy. 2.10. Chemotherapy. 2.11. Hematopoietic stem cell transplantation. 2.12. Hormonal therapy. 2.13. Biological therapies. 2.14. Clinical trials. 2.15. Long-term survival. 2.16. Prevention -- ch. 3. Principles of neutron capture therapy. 3.1. Boron Neutron Capture Therapy (BNCT). 3.2. Gadolinium Neutron Capture Therapy (GdNCT) -- ch. 4. Major Neutron Capture Therapy (NCT) drug prototypes. 4.1. BNCT agents: background and general requirements. 4.2. Boron compounds-based BNCT agents. 4.3. Boron-containing nanomaterial-based BNCT agents. 4.4. Major gadolinium neutron capture therapy drug types. 4.5. Combined Gadolinium and Boron Neutron Capture Therapy (GdBNCT) agents -- ch. 5. Neutron sources for NCT. 5.1. Introduction. 5.2. Fission-based reactors. 5.3. Accelerator-based neutron sources. 5.4. Other neutron sources -- ch. 6. NCT dosimetry and treatment planning. 6.1. NCT dosimetry and treatment planning. 6.1. BNCT dosimetry. 6.2. GdNCT dosimetry -- ch. 7. Selected in vitro and in vivo studies. 7.1. In vivo and in vitro studies involving BNCT. 7.2 In vivo and in vitro studies involving GdNCT. 7.3. In vitro and in vivo studies involving combined BNCT and GdNCT -- ch. 8. Clinical trials. 8.1. Clinical trials using Boron Neutron Capture Therapy (BNCT). 8.2. Clinical trials using Gadolinium Neutron Capture Therapy (GdNCT) -- ch. 9. Future perspectives for boron and gadolinium neutron capture therapies in cancer treatment
Summary The book focuses on two concurrent experimental therapies in cancer treatment known as Boron Neutron Capture Therapy (BNCT) and Gadolinium Neutron Capture Therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT and GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs has turned the area into the hottest one worthy of further investigation with the new clinical trials in the USA and elsewhere
Bibliography Includes bibliographical references (pages 215-240) and index
Subject Boron-neutron capture therapy.
Cancer -- Treatment.
Gadolinium-neutron capture therapy.
Form Electronic book
Author Hosmane, Narayan S.
World Scientific (Firm)
ISBN 9789814338684 (electronic bk.)
9814338680 (electronic bk.)