| Description |
1 online resource |
| Series |
Diagnostics and therapeutic advances in GI malignancies |
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Diagnostics and therapeutic advances in GI malignancies.
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| Contents |
Intro -- Preface -- Acknowledgements -- About the Book -- Contents -- Editors and Contributors -- Abbreviations -- Part I: Emerging Biomarkers for Gastrointestinal Cancer -- Chapter 1: Potential Role of Biomarkers, Biosensors, Technologies, and Computational Methods in Early Detection of Gastrointes ... -- 1.1 Introduction -- 1.2 Role of Biomarkers in Early Detection of Gastrointestinal Cancer -- 1.3 Role of Biosensors in Early Detection of Gastrointestinal Cancer -- 1.4 Role of Technologies in Early Detection of Gastrointestinal Cancer |
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1.5 Role of Computational Methods in Early Detection of Gastrointestinal Cancer -- 1.6 Significance -- References -- Chapter 2: Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer -- 2.1 Introduction -- 2.2 Diagnosis and Importance of Early Detection of Cancer -- 2.2.1 Diagnosis of Cancer -- 2.2.1.1 Tumor Testing for Biomarkers -- 2.2.1.2 Gene Tests -- 2.2.1.3 Cytogenetic Tests -- 2.2.1.4 Biochemical Tests -- 2.2.2 Importance of Early Detection of Cancer -- 2.3 Importance of Biomarkers -- 2.4 Biomarkers Available for Early Detection of Cancer |
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2.4.1 Disease State Biomarkers -- 2.4.2 Biomolecule Biomarkers -- 2.4.3 Other Criteria Biomarkers -- 2.5 Conclusions and Future Perspectives -- References -- Chapter 3: Development and Evaluation of Biomarkers for Early Detection of Cancer -- 3.1 Introduction -- 3.1.1 Definition -- 3.1.2 Evolution of Biomarkers -- 3.2 Types of Biomarkers -- 3.2.1 Classification of Biomarkers by Kumar and Sarin (2009) -- 3.2.1.1 DNA Biomarkers -- 3.2.1.2 RNA Biomarkers -- 3.2.1.3 Protein Biomarkers -- 3.2.2 Classification of Biomarkers by Abdul Baset Halim (2009) -- 3.2.2.1 Safety Biomarkers |
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3.2.2.2 Efficacy Biomarkers -- 3.2.3 Classification of Biomarkers by Frank and Hargreaves (2003) -- 3.2.3.1 Clinical Biomarkers -- 3.2.3.2 Microimaging Biomarkers -- 3.2.3.3 Next-Generation Biomarkers -- 3.2.4 Classification of Biomarkers by Turner and Hellerstein (2005) -- 3.2.4.1 Static Biomarkers -- 3.2.4.2 Kinetic Biomarkers -- 3.3 Volume of Business with Biomarkers in Medicine and Pharmaceutical Industry -- 3.3.1 Blockbusters -- 3.3.2 Niche Busters -- 3.4 Intellectual Property on Biomarkers -- 3.5 Stages in Development of Biomarkers -- 3.5.1 Discovery -- 3.5.1.1 Identification of Biomarkers |
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3.5.1.2 Study Protocol Proposal -- 3.5.1.3 Fit for Purpose -- 3.5.2 Assay Development -- 3.5.3 Commercialization of Biomarker -- 3.6 Applications -- 3.7 Future Perspectives of Biomarkers -- 3.8 Conclusions -- References -- Chapter 4: Prognostic Molecular Markers for Gastrointestinal Cancer -- 4.1 Introduction -- 4.2 Conventional Prognostic Markers -- 4.3 Unconventional (Noninvasive Prognostic Markers) -- 4.3.1 Metastatic Genic Prognostic Marker -- 4.3.1.1 HER2 -- 4.3.1.2 MET -- 4.3.1.3 VEGF -- 4.3.2 MSI -- 4.3.3 Genetic Polymorphism -- 4.3.4 Long-Noncoding RNA -- 4.3.5 Immune Checkpoint |
| Summary |
This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers |
| Subject |
Gastrointestinal system -- Cancer -- Diagnosis -- Technological innovations
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Tumor markers.
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Biomarkers, Tumor
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Medical genetics.
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Gastroenterology.
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Oncology.
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Nanotechnology.
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Medical -- Genetics.
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Medical -- Gastroenterology.
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Medical -- Oncology.
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Technology & Engineering -- Nanotechnology & MEMS.
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Tumor markers
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Diagnòstic.
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Càncer gastrointestinal.
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| Genre/Form |
Llibres electrònics.
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| Form |
Electronic book
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| Author |
Bramhachari, Pallaval Veera.
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Neelapu, Nageswara Rao Reddy
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| ISBN |
9789811544316 |
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981154431X |
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