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Author Sarkar, Sahotra, author.

Title Cut-and-paste genetics : a CRISPR revolution / Sahotra Sarkar
Published Lanham, Maryland : Rowman & Littlefield, [2021]


Description 1 online resource (xvii, 205 pages) : illustrations
Contents Preface -- 1. Breeding a Perfect Society -- Beginnings: Davenport and eugenics in the United States -- IQ and involuntary sterilization -- Genetics against eugenics -- Exporting sterilization -- The Watson scandal -- Establishing human genetics -- Davenport's dreams today -- 2. Molecular Diseases, Elusive Treatments -- The molecularization of biology -- Molecular diseases -- But no molecular medicine -- Dreams of editing genes -- Followed by stunning failure -- Recombinant DNA made no difference -- Gene editing BC (before CRISPR) -- 3. What Good Was the Human Genome Project? -- The sequence revealed -- Common diseases and common variants -- Medical irrelevance of the sequence -- Critiques of the HGP, past and present -- Evolution and architecture of the genome -- Evolutionary contingency -- 4. The CRISPR Revolution -- The CRISPR structure emerges -- Its function is decoded -- The mechanism of immunity -- Onward to gene editing -- The delivery problem -- Ubiquitous CRISPR --
5. Inevitable Eugenics? -- Eugenics in the news -- What is eugenics? -- Defining eugenics -- A working definition -- Inescapable eugenics? -- Matters of ethics -- 6. Elimination of Genetic Diseases -- The long reach of Huntington's disease -- The He Jiankui affair -- The ethics of human germline intervention -- The limits of current science -- Gene specificity and Lenin's brain -- A policy proposal -- Proceed with caution -- Liberal and moderate eugenics -- 7. Designer Baby Delusions -- Why not genetic enhancement? -- The normal and the enhanced -- Liberal eugenics and genetic enhancement -- Rationality of genetic enhancement -- Planned human obsolescence -- Where is the science? The case of intelligence -- Genomics and IQ -- What about physical traits -- Genetic reductionism -- Contextual developmental construction -- What is perfection? -- 8. A CRISPR Future -- Editing the human germline -- Gene drives -- The ethics of promoting extinction -- Biosecurity -- CRISPR without the hype
Summary "Bringing together historical and ethical insights on the revolutionary, Nobel prize winning CRISPR/Cas9 gene editing technology, this accessible book examines the history of human attempts to understand and control our evolution, how the CRISPR/Cas9 technology works and what it could mean for the elimination of genetic diseases"-- Provided by publisher
Bibliography Includes bibliographical references (pages 179-194) and index
Notes Description based on online resource; title from digital title page (viewed on September 23, 2021)
Subject Gene editing.
Gene editing -- Moral and ethical aspects
CRISPR-associated protein 9.
CRISPR (Genetics)
Gene Editing -- ethics
CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR-Associated Protein 9
Gene Editing -- history
Genetic Diseases, Inborn -- therapy
Gene Editing
CRISPR-associated protein 9
Gene editing
Form Electronic book
LC no. 2021015620
ISBN 9781786614391