Description |
1 online resource (xiii, 276 pages) : illustrations |
Contents |
The basic coalescent -- A Y-chromosome data set -- Data and theory -- The Wright-Fisher model -- Assumptions of the Wright-Fisher model -- The number of descendants of a gene in one generation -- The geometric distribution -- The exponential distribution -- The discrete-time coalescent -- Coalescence of a sample of two genes -- Coalescence of a sample of n genes -- Example: Effect of approximations -- The continuous time coalescent -- Calculating simple quantities on a coalescent tree -- The height of a tree -- The total branch length of a tree -- The effect of sampling more sequences -- The effective population size -- The Moran model -- Robustness of the coalescent -- From genealogies to sequences -- Mathematical models of alleles -- The infinite alleles model -- The infinite sites model -- Finite sites model -- The Wright-Fisher model with mutation -- Algorithms for simulating sequence evolution -- The probability of a sample configuration -- Infinite alleles model -- Infinite sites model -- Impossible ancestral states -- Quantities related to the infinite sites model -- The number of segregating sites -- Haplotypes -- Pairwise mismatch distribution -- Estimators of [theta] and Tajima's D -- Evolutionary versus sampling variance -- Example 1: The variable S[subscript n] -- Example 2: Tajima's estimator [pi] -- Trees and topologies -- Some terminology -- The jump process and the waiting time process -- The coalescent and phylogenetic trees -- Counting trees and topologies -- Gene trees -- How to build a gene tree |
Summary |
"This text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Authored by leading experts, and rich in examples and illustrations, Gene Genealogies, Variation and Evolution is highly suitable for a graduate course in statistics; population, molecular and medical genetics; and for bioscience and medicine and students studying the evolution of human population and disease. It is also a reference for bioscientists and statisticians in the pharmaceutical industry and academia."--Jacket |
Analysis |
nucleotidenvolgordes |
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nucleotide sequences |
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dna sequencing |
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genetische variatie |
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genetic variation |
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genetische diversiteit |
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genetic diversity |
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populatiegenetica |
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population genetics |
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gegevensanalyse |
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data analysis |
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waarschijnlijkheidstheorie |
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probability theory |
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Population and Quantitative Genetics |
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Kwantitatieve- en populatiegenetica |
Bibliography |
Includes bibliographical references (pages 259-271) and index |
Notes |
Print version record |
Subject |
Population genetics -- Mathematical models.
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Population genetics.
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Gene mapping.
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Genetics -- Mathematical models.
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Genetics, Population
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Chromosome Mapping
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Models, Genetic
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SCIENCE -- Life Sciences -- Genetics & Genomics.
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Population genetics
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Genetics -- Mathematical models
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Gene mapping
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Population genetics -- Mathematical models
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Evolution
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Genanalyse
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Mathematisches Modell
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Populationsgenetik
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Rekombination
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Genetik
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Koaleszenz
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Populatiegenetica.
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Coalescentie.
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Variaties.
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Biometrie.
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Genetica de populacʹoes (modelos matematicos)
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Genetica (evolucʹao)
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Form |
Electronic book
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Author |
Schierup, Mikkel H
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Wiuf, Carsten
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ISBN |
1423770803 |
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9781423770800 |
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9786610758982 |
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6610758980 |
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