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Genes -- Miscellanea : Genes, development, and cancer : the life and work of Edward B. Lewis / edited with commentary by Howard D. Lipshitz  2007 1
 

Genes, Mitochondrial -- See Also DNA, Mitochondrial


Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins
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Genes, Mitochondrial   2
  Genes, Modifier -- 4 Related Subjects   4
 

Genes, myc -- See Also Proto-Oncogene Proteins c-myc


Basic helix-loop-helix transcription factors encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis
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Genes, myc   2
 

Genes, N-myc -- See Genes, myc


Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8
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Genes, N-ras -- See Genes, ras


Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein
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Genes, Neoplasm -- See Also Neoplasm Proteins


Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm
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Genes, Neoplasm.   13
Genes, Neoplasm -- genetics : Mutant p53 and MDM2 in cancer / Swati Palit Deb, Sumitra Deb, editor  2014 1
Genes, Neoplasm -- physiology : Cancer systems biology / edited by Edwin Wang  2010 1
 

Genes, neu -- See Genes, erbB-2


The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2
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Genes, Neurofibromatosis 1 -- See Also Neurofibromatosis 1


An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS)
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Genes, nf 2 -- See Genes, Neurofibromatosis 2


Tumor suppressor genes located on the long arm of human chromosome 22. Mutation or loss of these genes causes NEUROFIBROMATOSIS 2
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Genes, nf2 -- See Genes, Neurofibromatosis 2


Tumor suppressor genes located on the long arm of human chromosome 22. Mutation or loss of these genes causes NEUROFIBROMATOSIS 2
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Genes, Onco-Suppressor -- See Genes, Tumor Suppressor


Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible
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Genes, Overlapping : Information- and communication theory in molecular biology / Martin Bossert, editor  2018 1
 

Genes, p53 -- See Also Tumor Suppressor Protein p53


Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER
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Genes, p53   5
Genes, p53 -- genetics : DNA research, genetics, and cell biology / Tsisana Shartava, editor  2011 1
Genes, p53 -- physiology   3
Genes -- Patents   11
Genes -- Patents -- Moral and ethical aspects : Body corporate : who owns your genes? / produced by Wayne Harley  2011 1
Genes -- Periodicals   6
Genes -- Philosophy : Genes : a philosophical inquiry / Gordon Graham  2002 1
Genes -- physiology.   5
 

Genes, Plant -- See Also Genome, Plant


The genetic complement of a plant (PLANTS) as represented in its DNA
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Genes, Plant   6
Genes, Plant -- genetics   2
Genes, Plant -- physiology : Programmed cell death in plants / edited by John Gray  2004 1
 

Genes, Pleiotropic -- See Genetic Pleiotropy


A phenomenon in which multiple and diverse phenotypic outcomes are influenced by a single gene (or single gene product.)
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Genes -- Popular works.   2
  Genes, ras -- 2 Related Subjects   2
Genes, ras   5
Genes, ras -- physiology : Therapeutic targeting of RAS mutant cancers / Edward C. Stites, Kendra Paskvan and Shumei Kato  2022 1
Gènes rĂ©gulateurs. : Microarrays and transcription networks / [edited by] M. Frances Shannon, Sudha Rao  2006 1
 

Genes, Regulator -- See Also Transcriptional Activation


Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes
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Genes, Reiterated -- See Multigene Family


A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
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Genes, Reporter   5
Genes, Reporter -- genetics. : Bacterial sensors : synthetic design and application principles / Jan Roelof van der Meer  2011 1
Genes -- Research : Quantum. Series 2, Episode 9 / produced by Geoffrey Burchfield, Naomi Lumsdaine, Paul Costello and Richard Corfield  2013 1
Genes -- Research -- History : Proteins, enzymes, genes : the interplay of chemistry and biology / Joseph S. Fruton  1999 1
Genes -- Research -- Periodicals : DNA research (Online)    1
 

Genes, Retinoblastoma -- See Also Retinoblastoma


A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
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Genes, Retinoblastoma -- physiology : Rb and tumorigenesis / [edited by] Maurizio Fanciulli  2006 1
 

Genes, Selfish -- See Repetitive Sequences, Nucleic Acid


Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES)
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Genes -- Social aspects   2
 

Genes, Spliced -- See DNA, Recombinant


Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected
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Genes, sry -- See Also Sex Determination Processes


The mechanisms by which the SEX of an individual's GONADS are fixed
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