| Description |
1 online resource |
| Series |
Translational epigenetics series |
|
Translational epigenetics series.
|
| Contents |
The state of the art of epigenetic technologies -- Technologies for the measurement and mapping of genomic 5-methylcytosine and 5-hydroxymethylcytosine -- High-throughput sequencing-based mapping of cytosine modifications -- Application of mass spectrometry in translational epigenetics -- Techniques analyzing chromatin modifications at specific single loci -- Comprehensive analysis of mammalian linker-histone variants and their mutants -- Crystallography-based mechanistic insights into epigenetic regulation -- Chemical and genetic approaches to study histone modifications -- Peptide microarrays for profiling of epigenetic targets -- Current methods for methylome profiling -- Bioinformatics and biostatistics in mining epigenetic disease markers and targets -- Computational modeling to elucidate molecular mechanisms of epigenetic memory -- DNA methyltransferase inhibitors for cancer therapy -- Histone acetyltransferases: enzymes, assays, and inhibitors -- In vitro histone deacetylase activity screening: making a case for better assays -- Enzymatic assays of histone methyltransferase enzymes -- Histone methyltransferase inhibitors for cancer therapy -- Discovery of histone demethylase inhibitors -- Histone demethylases: background, purification, and detection -- Animal model study of epigenetic inhibitors -- Index |
| Summary |
Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. Discusses technologies that are critical for epigenetic research and application Includes epigenetic applications for state-of-the-art technologies Contains a global perspective on the future of epigenetics |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Vendor-supplied metadata |
| Subject |
Epigenetics.
|
|
Gene therapy.
|
|
Acetylation.
|
|
Genetic Therapy
|
|
Acetylation
|
|
DNA Methylation -- genetics
|
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Epigenomics
|
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Genetic Predisposition to Disease
|
|
SCIENCE -- Life Sciences -- Biochemistry.
|
|
Gene therapy
|
|
Acetylation
|
|
Epigenetics
|
| Form |
Electronic book
|
| Author |
Zheng, Y. George, editor
|
| ISBN |
9780128013274 |
|
0128013273 |
|
0128010800 |
|
9780128010808 |
|
