| Description |
1 online resource (xxiii, 676 pages) : illustrations |
| Contents |
Human genome epidemiology: the road map revisited -- Principles of analysis of germline genetics -- The public health genomics enterprise -- Navigating the evolving knowledge of human genetic variation in health and disease -- The global emergence of epidemiological biobanks: opportunities and challenges -- Case-control and cohort studies in the age of genome-wide associations -- The emergence of networks in human genome epidemiology: challenges and opportunities -- Design and analysis issues in genome-wide association studies -- The challenge of assessing complex gene-environment and gene-gene interactions -- STrengthening the REporting of genetic association studies (STREGA)-an extension of the STROBE statement -- Integration of the evidence on gene-disease associations: methods of HuGE reviews -- Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases -- Colorectal cancer -- Childhood leukemias -- Bladder cancer -- Type 2 diabetes -- Osteoporosis -- Preterm birth -- Coronary heart disease -- Schizophrenia -- Mendelian randomization: the contribution of genetic epidemiology to elucidating environmentally modifiable causes of disease -- Evaluation of predictive genetic tests for common diseases: bridging epidemiological, clinical, and public health measures -- The evaluation of genomic applications in practice and prevention (EGAPP) initiative: methods of the EGAPP working group -- Rapid, evidence-based reviews of genetic tests -- Role of social and behavioral research in assessing the utility of genetic information -- Assessing the evidence for clinical utility in newborn screening -- The role of epidemiology in assessing the potential clinical impact of pharmacogenomics -- The human epigenome and cancer -- The use of family history in public health practice: the epidemiologic view -- Cytochrome P450 testing in the treatment of depression -- A rapid-ACCE review of CYP2CP and VKORC1 allele testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding -- Hereditary hemochromatosis: population screening for gene mutations |
| Summary |
This text describes the role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It provides a foundation that should help researchers, policy makers and practitioners integrate genomics into medical and public health practice |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Genetic disorders -- Epidemiology
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Medical genetics -- Methodology
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Genomics.
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Genetic screening.
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Human genome.
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Genetics, Medical -- methods
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Genetic Diseases, Inborn -- epidemiology
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Genetic Predisposition to Disease -- epidemiology
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Genetic Testing
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Genome, Human
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Genomics
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Human genome.
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Genetic screening.
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Genomics.
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| Form |
Electronic book
|
| Author |
Khoury, Muin J
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| ISBN |
9780195398441 |
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0195398440 |
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9780199776023 |
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0199776024 |
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