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Title Animal models of cancer predisposition syndromes / volume editors, Hiroshi Hiai, Okio Hino
Published Basel ; New York : Karger, ©1999


Description 1 online resource (vii, 175 pages) : illustrations (some color)
Series Progress in experimental tumor research ; v. 35
Progress in experimental tumor research ; v. 35
Contents Contents -- Preface -- Multiple Genes Governing Biological Functions in the Genetic Backgrounds of LaboratoryMice and Asian Wild Mice -- Overview of Transgenic and Gene Knockout Mice -- Alkylation Carcinogenesis in Mice with Altered Levels of DNA Repair Methyltransferase -- Cancer Predisposition inMutantMice Defective in the XPC DNA Repair Gene -- Myeloid Leukemia: Disease Genes and MouseModels -- Genetic and Epigenetic Susceptibility to Endogenous Retrovirus-Induced Lymphomas in SL Mice -- Inheritance of Pulmonary Adenoma Susceptibility in Mice
TSC2 GeneMutant (Eker) Rat Model of a Mendelian Dominantly Inherited CancerApc Gene KnockoutMice as a Model for Familial Adenomatous Polyposis -- A Rat Model System for Predisposition to Stomach Cancer -- Genetic and Hormonal Regulation of Murine Hepatocarcinogenesis -- Genetics of Skin Tumor Promotion -- The Genetic Components of Susceptibility to Breast Cancer in the Rat -- Author Index
Summary Studies of both spontaneous and environmentally induced tumors have demonstrated that there is considerable variation among individuals in their response to carcinogenesis, suggesting that genetic factors influence the likelihood of developing cancer. The increasing availability of genetic markers has enabled researchers to analyze polygenic traits such as cancer predisposition. Animal models have proved to be useful experimental tools for identifying and characterizing such genetic factors. Such a comparative approach helps to identify factors that animals and man have in common and to elucidate the basic mechanism of determining susceptibility. This book brings together some of the most recent advances made in the genetic analysis of cancer susceptibility using animal models. Leading investigators in the field present model systems for studying cancers including liver and stomach cancer, breast cancer, myeloid leukemia, retrovirus-induced lymphoma, pulmonary adenoma and familial adenomatous polyposis. An overview of transgenic and gene knockout mice is given, and in several chapters the implications of these findings for human cancers are discussed. Providing an excellent survey of the field, the book is recommended reading for all scientists and graduate students in experimental cancer research and cancer genomics
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Cancer -- Genetic aspects -- Animal models
Cancer -- Risk factors -- Animal models
Diseases -- Animal models.
Genetic markers.
Neoplasms -- genetics
Disease Models, Animal
Genetic Markers
Genetic Predisposition to Disease
Diseases -- Animal models.
Genetic markers.
Krebs <Medizin> -- Prädisposition -- Tiermodell -- Aufsatzsammlung.
Prädisposition -- Krebs <Medizin> -- Tiermodell -- Aufsatzsammlung.
Form Electronic book
Author Hiai, Hiroshi
Hino, Okio
S. Karger (Firm)
ISBN 9783318003253